This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5eo0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5eo0 is ON HOLD until Paper Publication
+
==Crystal Structure of HLA-B0702-RFL9==
-
 
+
<StructureSection load='5eo0' size='340' side='right' caption='[[5eo0]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-
Authors: Josephs, T.M., Gras, S., Rossjohn, J.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5eo0]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EO0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EO0 FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5eo1|5eo1]]</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eo0 OCA], [http://pdbe.org/5eo0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eo0 RCSB], [http://www.ebi.ac.uk/pdbsum/5eo0 PDBsum]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/1B07_HUMAN 1B07_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Gras, S]]
 +
[[Category: Josephs, T M]]
[[Category: Rossjohn, J]]
[[Category: Rossjohn, J]]
-
[[Category: Gras, S]]
+
[[Category: Hiv]]
-
[[Category: Josephs, T.M]]
+
[[Category: Hla b*0702]]
 +
[[Category: Immune escape]]
 +
[[Category: Immune system]]
 +
[[Category: T cell]]
 +
[[Category: Tcr]]

Revision as of 18:19, 26 February 2016

Crystal Structure of HLA-B0702-RFL9

5eo0, resolution 1.70Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5eo0"
Personal tools