5ev1
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure I of Intact U2AF65 Recognizing a 3' Splice Site Signal== | |
| - | + | <StructureSection load='5ev1' size='340' side='right' caption='[[5ev1]], [[Resolution|resolution]] 2.04Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ev1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EV1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EV1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BRU:5-BROMO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>BRU</scene>, <scene name='pdbligand=DU:2-DEOXYURIDINE-5-MONOPHOSPHATE'>DU</scene></td></tr> |
| - | [[Category: Jenkins, J | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ev2|5ev2]], [[5ev3|5ev3]], [[5ev4|5ev4]]</td></tr> |
| - | [[Category: Kielkopf, C | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ev1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ev1 OCA], [http://pdbe.org/5ev1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ev1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ev1 PDBsum]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/U2AF2_HUMAN U2AF2_HUMAN]] Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:15009664</ref> <ref>PMID:19470458</ref> <ref>PMID:19574390</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Agrawal, A A]] | ||
| + | [[Category: Jenkins, J L]] | ||
| + | [[Category: Kielkopf, C L]] | ||
| + | [[Category: Polypyrimidine tract]] | ||
| + | [[Category: Protein-rna complex]] | ||
| + | [[Category: Rna binding protein-rna complex]] | ||
| + | [[Category: Rna recognition motif]] | ||
| + | [[Category: Rna splicing factor]] | ||
Revision as of 18:20, 26 February 2016
Structure I of Intact U2AF65 Recognizing a 3' Splice Site Signal
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