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Revision as of 18:59, 26 February 2016


This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439.


Contents

Penicillin binding protein/lactivicin (inhibitor) (2jch)[1]

by Tyler Carpenter, Samuel Pierce, Hyunjoon Choi, Anton El Khoury and Tiankai Zhang

Student Projects for UMass Chemistry 423 Spring 2016

Introduction

2jch, Saves cells from dying since the appearance of life

Drag the structure with the mouse to rotate

Outline: 1) Why is it important? Penicillin-binding proteins are essential for cell wall biogenesis. General info about bacterial cell wall biogenesis. Also, how bacteria mutate in order to avoid binding to beta-lactam. 2) Ligands, in particular . Also, how PBP binds lactivicin. Sample green scene: Penicillin-binding protein has four ligands, one of which is



















=Overall Structure

The secondary structures of PBP have certain affects on ligands

2jch, insert caption here

Drag the structure with the mouse to rotate





















Binding Interactions

2jch, Insert caption here

Drag the structure with the mouse to rotate





















Additional Features

2jch, Insert caption here

Drag the structure with the mouse to rotate





















Quiz Question 1

2jch, Insert caption here

Drag the structure with the mouse to rotate





















See Also

Credits

Introduction - Anton El Khoury

Overall Structure - Tyler Carpenter

Drug Binding Site - name of team member

Additional Features - name of team member

Quiz Question 1 - Samuel Pierce

References

  1. ↑ Macheboeuf P, Fischer DS, Brown T Jr, Zervosen A, Luxen A, Joris B, Dessen A, Schofield CJ. Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins. Nat Chem Biol. 2007 Sep;3(9):565-9. Epub 2007 Aug 5. PMID:17676039 doi:10.1038/nchembio.2007.21
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