Sandbox Reserved 429
From Proteopedia
| Line 30: | Line 30: | ||
==Additional Features== | ==Additional Features== | ||
'''1)role in antibiotics and resistance''' | '''1)role in antibiotics and resistance''' | ||
| - | the role of PBPs in its synthesis is a very good target for drugs of selective toxicity | + | the role of PBPs<scene name='48/483886/Conserved_residues_of_pbp/2'>TextToBeDisplayed</scene> in its synthesis is a very good target for drugs of selective toxicity |
'''2)different PBPs and how they are classified into diverse categories''' | '''2)different PBPs and how they are classified into diverse categories''' | ||
found as both membrane-bound and cytoplasmic proteins | found as both membrane-bound and cytoplasmic proteins | ||
| - | '''3) | + | '''3)TextToBeDisplayed</scene>work as enzyme to catalyze synthesis of peptidoglycan''' |
<Structure load='2jch' size='300' frame='true' align='right' caption='2jch, Insert caption here' scene='Insert optional scene name here' /> | <Structure load='2jch' size='300' frame='true' align='right' caption='2jch, Insert caption here' scene='Insert optional scene name here' /> | ||
Revision as of 05:05, 27 February 2016
| This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439. |
Contents |
Penicillin binding protein/lactivicin (inhibitor) (2jch)[1]
by Tyler Carpenter, Samuel Pierce, Hyunjoon Choi, Anton El Khoury and Tiankai Zhang
Student Projects for UMass Chemistry 423 Spring 2016
Introduction
|
Outline:
1) Why is it important? Penicillin-binding proteins are essential for cell wall biogenesis. General info about bacterial cell wall biogenesis. Also, how bacteria mutate in order to avoid binding to beta-lactam.
2) Ligands, in particular . Also, how PBP binds lactivicin.
Sample green scene: Penicillin-binding protein has four ligands, one of which is
=Overall Structure
The secondary structures of PBP have certain affects on ligands Ligand has oxyanion hole to further binding potential. How does this help?
|
Binding Interactions
|
Additional Features
1)role in antibiotics and resistance the role of PBPs in its synthesis is a very good target for drugs of selective toxicity
2)different PBPs and how they are classified into diverse categories found as both membrane-bound and cytoplasmic proteins
3)TextToBeDisplayed</scene>work as enzyme to catalyze synthesis of peptidoglycan
|
Quiz Question 1
Question related to PBP evolution and developing resistance to ß-lactams, likely related to active site mutations.
Shows the from most conserved to most variable.
|
See Also
Credits
Introduction - Anton El Khoury
Overall Structure - Tyler Carpenter
Drug Binding Site - name of team member
Additional Features - Tiankai Zhang
Quiz Question 1 - Samuel Pierce
References
- ↑ Macheboeuf P, Fischer DS, Brown T Jr, Zervosen A, Luxen A, Joris B, Dessen A, Schofield CJ. Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins. Nat Chem Biol. 2007 Sep;3(9):565-9. Epub 2007 Aug 5. PMID:17676039 doi:10.1038/nchembio.2007.21
