3roh

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==Crystal Structure of Leukotoxin (LukE) from Staphylococcus aureus subsp. aureus COL.==
==Crystal Structure of Leukotoxin (LukE) from Staphylococcus aureus subsp. aureus COL.==
<StructureSection load='3roh' size='340' side='right' caption='[[3roh]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='3roh' size='340' side='right' caption='[[3roh]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3roh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_tch70 Staphylococcus aureus subsp. aureus tch70]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ROH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ROH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3roh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_70 Staphylococcus aureus subsp. aureus 70]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ROH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ROH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HMPREF0773_11197, lukE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=548475 Staphylococcus aureus subsp. aureus TCH70])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HMPREF0773_11197, lukE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=548475 Staphylococcus aureus subsp. aureus 70])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3roh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3roh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3roh RCSB], [http://www.ebi.ac.uk/pdbsum/3roh PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3roh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3roh OCA], [http://pdbe.org/3roh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3roh RCSB], [http://www.ebi.ac.uk/pdbsum/3roh PDBsum]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Staphylococcal leukotoxins are a family of beta-barrel, bicomponent, pore-forming toxins with membrane-damaging functions. These bacterial exotoxins share sequence and structural homology and target several host-cell types. Leukotoxin ED (LukED) is one of these bicomponent pore-forming toxins that Staphylococcus aureus produces in order to suppress the ability of the host to contain the infection. The recent delineation of the important role that LukED plays in S. aureus pathogenesis and the identification of its protein receptors, combined with its presence in S. aureus methicillin-resistant epidemic strains, establish this leukocidin as a possible target for the development of novel therapeutics. Here, the crystal structures of the water-soluble LukE and LukD components of LukED have been determined. The two structures illustrate the tertiary-structural variability with respect to the other leukotoxins while retaining the conservation of the residues involved in the interaction of the protomers in the bipartite leukotoxin in the pore complex.
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Crystal structures of the components of the Staphylococcus aureus leukotoxin ED.,Nocadello S, Minasov G, Shuvalova L, Dubrovska I, Sabini E, Bagnoli F, Grandi G, Anderson WF Acta Crystallogr D Struct Biol. 2016 Jan;72(Pt 1):113-20. doi:, 10.1107/S2059798315023207. Epub 2016 Jan 1. PMID:26894539<ref>PMID:26894539</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3roh" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Staphylococcus aureus subsp. aureus tch70]]
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[[Category: Staphylococcus aureus subsp. aureus 70]]
[[Category: Anderson, W F]]
[[Category: Anderson, W F]]
[[Category: Bagnoli, F]]
[[Category: Bagnoli, F]]

Revision as of 06:58, 2 March 2016

Crystal Structure of Leukotoxin (LukE) from Staphylococcus aureus subsp. aureus COL.

3roh, resolution 3.20Å

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