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Fructose-1,6-bisphosphatase

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{{STRUCTURE_1bk4| PDB=1bk4 | SIZE=300| SCENE=Fructose-1,6-bisphosphatase/Cv/1 |right|CAPTION=Fructose-1,6-bisphosphatase complex with sulfate and Mg+2 ion (green) [[1bk4]] }}
{{STRUCTURE_1bk4| PDB=1bk4 | SIZE=300| SCENE=Fructose-1,6-bisphosphatase/Cv/1 |right|CAPTION=Fructose-1,6-bisphosphatase complex with sulfate and Mg+2 ion (green) [[1bk4]] }}
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== Function ==
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'''Fructose-1,6-bisphosphatase''' (FBP) is an enzyme in the glucose generating pathway which converts fructose-1,6-bisphosphate to fructose 6-phosphate (F6P).
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'''Fructose-1,6-bisphosphatase''' (FBP) is an enzyme in the glucose generating pathway which converts fructose-1,6-bisphosphate to fructose 6-phosphate (F6P)<ref>PMID:8382485</ref>. FBP activity in hibernating animals is significantly reduced<ref>PMID:9505421</ref>.
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== Relevance ==
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FBP inhibitors are studied as drug candidates for the treatment of diabetes type 2<ref>PMID:16731838</ref>.
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== Disease ==
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FBP deficiency results in hyperglycemia<ref>PMID:21484576</ref>.
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== References ==
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<references/>
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[[Category:Topic Page]]

Revision as of 11:21, 2 March 2016

Template:STRUCTURE 1bk4

Contents

Function

Fructose-1,6-bisphosphatase (FBP) is an enzyme in the glucose generating pathway which converts fructose-1,6-bisphosphate to fructose 6-phosphate (F6P)[1]. FBP activity in hibernating animals is significantly reduced[2].

Relevance

FBP inhibitors are studied as drug candidates for the treatment of diabetes type 2[3].

Disease

FBP deficiency results in hyperglycemia[4].






3D Structures of Fructose-1,6-bisphosphatase

Updated on 02-March-2016

References

  1. ↑ Zhang Y, Liang JY, Lipscomb WN. Structural similarities between fructose-1,6-bisphosphatase and inositol monophosphatase. Biochem Biophys Res Commun. 1993 Feb 15;190(3):1080-3. PMID:8382485
  2. ↑ Storey KB. Metabolic regulation in mammalian hibernation: enzyme and protein adaptations. Comp Biochem Physiol A Physiol. 1997 Dec;118(4):1115-24. PMID:9505421
  3. ↑ van Poelje PD, Potter SC, Chandramouli VC, Landau BR, Dang Q, Erion MD. Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in Zucker diabetic fatty rats. Diabetes. 2006 Jun;55(6):1747-54. PMID:16731838 doi:http://dx.doi.org/10.2337/db05-1443
  4. ↑ van Poelje PD, Potter SC, Erion MD. Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes. Handb Exp Pharmacol. 2011;(203):279-301. doi: 10.1007/978-3-642-17214-4_12. PMID:21484576 doi:http://dx.doi.org/10.1007/978-3-642-17214-4_12

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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