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Fructose-1,6-bisphosphatase

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<StructureSection load='3kc0' size='350' side='right' caption='Human liver ructose-1,6-bisphosphatase complex with inhibitor (PDB entry [[3kc0]])' scene=''>
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<StructureSection load='3kc0' size='350' side='right' caption='Fructose-1,6-bisphosphatase complex with sulfate and Mg+2 ion (green (PDB entry [[3kc0]])' scene=''>
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== Function ==
== Function ==
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FBP deficiency results in hyperglycemia<ref>PMID:21484576</ref>.
FBP deficiency results in hyperglycemia<ref>PMID:21484576</ref>.
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</StructureSection>
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== 3D Structures of Fructose-1,6-bisphosphatase ==
== 3D Structures of Fructose-1,6-bisphosphatase ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

Revision as of 11:27, 2 March 2016

Human liver ructose-1,6-bisphosphatase complex with inhibitor (PDB entry 3kc0)

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3D Structures of Fructose-1,6-bisphosphatase

Updated on 02-March-2016

References

  1. ↑ Zhang Y, Liang JY, Lipscomb WN. Structural similarities between fructose-1,6-bisphosphatase and inositol monophosphatase. Biochem Biophys Res Commun. 1993 Feb 15;190(3):1080-3. PMID:8382485
  2. ↑ Storey KB. Metabolic regulation in mammalian hibernation: enzyme and protein adaptations. Comp Biochem Physiol A Physiol. 1997 Dec;118(4):1115-24. PMID:9505421
  3. ↑ van Poelje PD, Potter SC, Chandramouli VC, Landau BR, Dang Q, Erion MD. Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in Zucker diabetic fatty rats. Diabetes. 2006 Jun;55(6):1747-54. PMID:16731838 doi:http://dx.doi.org/10.2337/db05-1443
  4. ↑ van Poelje PD, Potter SC, Erion MD. Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes. Handb Exp Pharmacol. 2011;(203):279-301. doi: 10.1007/978-3-642-17214-4_12. PMID:21484576 doi:http://dx.doi.org/10.1007/978-3-642-17214-4_12

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