2n1n
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of VSTx1== | |
| - | + | <StructureSection load='2n1n' size='340' side='right' caption='[[2n1n]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2n1n]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N1N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N1N FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1s6x|1s6x]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n1n OCA], [http://pdbe.org/2n1n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n1n RCSB], [http://www.ebi.ac.uk/pdbsum/2n1n PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/VSTX1_GRARO VSTX1_GRARO]] Inhibits sodium channels Nav1.7/SCN9A and potassium channels Kv11.1/KCNH2. Also binds the voltage-sensor domain of the potassium channel KvAP (from the archaeon Aeropyrum pernix) with very slow apparent binding kinetics and affects channel gating. Reaches its target by dynamically partitioning into anionic or zwitterionic headgroup lipid membranes. May bind to the open state of KvAP.<ref>PMID:15241419</ref> <ref>PMID:15287735</ref> <ref>PMID:17002285</ref> <ref>PMID:19955179</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: King, G F]] | ||
| + | [[Category: Lau, H Y]] | ||
[[Category: Mobli, M]] | [[Category: Mobli, M]] | ||
| - | [[Category: | + | [[Category: Toxin]] |
| - | + | ||
Revision as of 15:13, 2 March 2016
Solution structure of VSTx1
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Categories: King, G F | Lau, H Y | Mobli, M | Toxin
