5e6s

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'''Unreleased structure'''
 
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The entry 5e6s is ON HOLD until Paper Publication
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==Structures of leukocyte integrin aLB2: The aI domain, the headpiece, and the pocket for the internal ligand==
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<StructureSection load='5e6s' size='340' side='right' caption='[[5e6s]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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Authors: Springer, T.A., Sen, M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5e6s]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E6S FirstGlance]. <br>
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Description: Structures of leukocyte integrin aLB2: The aI domain, the headpiece, and the pocket for the internal ligand
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5e6r|5e6r]], [[5e6u|5e6u]]</td></tr>
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[[Category: Springer, T.A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e6s OCA], [http://pdbe.org/5e6s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e6s RCSB], [http://www.ebi.ac.uk/pdbsum/5e6s PDBsum]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1 (LAD1) [MIM:[http://omim.org/entry/116920 116920]]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.<ref>PMID:7509236</ref> <ref>PMID:1346613</ref> <ref>PMID:1968911</ref> <ref>PMID:1694220</ref> <ref>PMID:1590804</ref> <ref>PMID:1352501</ref> <ref>PMID:1347532</ref> <ref>PMID:7686755</ref> <ref>PMID:9884339</ref> <ref>PMID:20529581</ref> <ref>PMID:20549317</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/ITAL_HUMAN ITAL_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. [[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.<ref>PMID:18587400</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Sen, M]]
[[Category: Sen, M]]
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[[Category: Springer, T A]]
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[[Category: Cell adhesion]]
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[[Category: Lymphocyte function-associated antigen-1]]

Revision as of 15:24, 2 March 2016

Structures of leukocyte integrin aLB2: The aI domain, the headpiece, and the pocket for the internal ligand

5e6s, resolution 2.15Å

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