5eu3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "5eu3" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5eu3 is ON HOLD until Paper Publication
+
==HLA Class I antigen==
-
 
+
<StructureSection load='5eu3' size='340' side='right' caption='[[5eu3]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
-
Authors: Rizkallah, P.J., Bianchi, V., Cole, D.K., Sewell, A.K.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5eu3]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EU3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EU3 FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eu3 OCA], [http://pdbe.org/5eu3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eu3 RCSB], [http://www.ebi.ac.uk/pdbsum/5eu3 PDBsum]</span></td></tr>
-
[[Category: Cole, D.K]]
+
</table>
-
[[Category: Sewell, A.K]]
+
== Disease ==
-
[[Category: Rizkallah, P.J]]
+
[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Bianchi, V]]
[[Category: Bianchi, V]]
 +
[[Category: Cole, D K]]
 +
[[Category: Rizkallah, P J]]
 +
[[Category: Sewell, A K]]
 +
[[Category: 1e6-tcr]]
 +
[[Category: Cross-reactivity]]
 +
[[Category: Hla-a02]]
 +
[[Category: Immune system]]
 +
[[Category: Immuno]]

Revision as of 15:25, 2 March 2016

HLA Class I antigen

5eu3, resolution 1.97Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5eu3"
Personal tools