5f3k

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'''Unreleased structure'''
 
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The entry 5f3k is ON HOLD until Paper Publication
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==X-Ray Crystallographic Structure of hTrap1 N-terminal Domain-apo==
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<StructureSection load='5f3k' size='340' side='right' caption='[[5f3k]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
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Authors: Sung, N., Lee, J., Kim, J., Chang, C., Joachimiak, A., Lee, S., Tsai, F.T.F.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5f3k]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F3K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F3K FirstGlance]. <br>
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Description: X-Ray Crystallographic Structure of hTrap1 N-terminal Domain-apo
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5f5r|5f5r]]</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f3k OCA], [http://pdbe.org/5f3k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f3k RCSB], [http://www.ebi.ac.uk/pdbsum/5f3k PDBsum]</span></td></tr>
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[[Category: Sung, N]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TRAP1_HUMAN TRAP1_HUMAN]] Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.<ref>PMID:23525905</ref> <ref>PMID:23564345</ref> <ref>PMID:23747254</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Chang, C]]
[[Category: Joachimiak, A]]
[[Category: Joachimiak, A]]
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[[Category: Kim, J]]
[[Category: Lee, J]]
[[Category: Lee, J]]
[[Category: Lee, S]]
[[Category: Lee, S]]
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[[Category: Kim, J]]
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[[Category: Sung, N]]
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[[Category: Tsai, F.T.F]]
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[[Category: Tsai, F T.F]]
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[[Category: Chang, C]]
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[[Category: Apo]]
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[[Category: Chaperone]]
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[[Category: Hsp90]]
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[[Category: Trap1]]

Revision as of 15:26, 2 March 2016

X-Ray Crystallographic Structure of hTrap1 N-terminal Domain-apo

5f3k, resolution 1.82Å

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