5i08
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Prefusion structure of a human coronavirus spike protein== | |
| - | + | <StructureSection load='5i08' size='340' side='right' caption='[[5i08]], [[Resolution|resolution]] 4.04Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5i08]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I08 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i08 OCA], [http://pdbe.org/5i08 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i08 RCSB], [http://www.ebi.ac.uk/pdbsum/5i08 PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/SPIKE_CVHN5 SPIKE_CVHN5]] S1 attaches the virion to the cell membrane by interacting with cell receptors, initiating the infection. S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Presumably interacts with target cell lipid raft after cell attachment (By similarity). |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Turner, H | + | </StructureSection> |
| + | [[Category: Corbett, K S]] | ||
| + | [[Category: Cottrell, C A]] | ||
| + | [[Category: Graham, B S]] | ||
| + | [[Category: Kirchdoerfer, R N]] | ||
| + | [[Category: McLellan, J S]] | ||
| + | [[Category: Pallesen, J]] | ||
| + | [[Category: Turner, H L]] | ||
[[Category: Wang, N]] | [[Category: Wang, N]] | ||
| - | [[Category: | + | [[Category: Ward, A B]] |
| - | [[Category: | + | [[Category: Yassine, H M]] |
| - | [[Category: | + | [[Category: Coronavirus]] |
| - | [[Category: | + | [[Category: Glycoprotein]] |
| - | [[Category: | + | [[Category: Prefusion]] |
| + | [[Category: Viral protein]] | ||
Revision as of 15:30, 2 March 2016
Prefusion structure of a human coronavirus spike protein
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