Sandbox Reserved 425
From Proteopedia
(Difference between revisions)
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[[Student Projects for UMass Chemistry 423 Spring 2016]] | [[Student Projects for UMass Chemistry 423 Spring 2016]] | ||
| + | <StructureSection load='4uxq' size='350' side='right' caption='caption for Molecular Playground (PDB entry [[4uxq]])' scene=''> | ||
==Introduction== | ==Introduction== | ||
| - | <Structure load='1stp' size='300' frame='true' align='right' caption='4uxq, depiction of secondary structure elements' scene='Insert optional scene name here' /> | ||
•Plays a role in a variety of cancers | •Plays a role in a variety of cancers | ||
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<scene name='48/483882/Secondary_structure/1'>Secondary Structure</scene> | <scene name='48/483882/Secondary_structure/1'>Secondary Structure</scene> | ||
| - | <br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br> | ||
==Overall Structure== | ==Overall Structure== | ||
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•Identical amino acid sequence to cI44 with the exception of 1 residue.<ref>PMID: 7680645</ref> | •Identical amino acid sequence to cI44 with the exception of 1 residue.<ref>PMID: 7680645</ref> | ||
| - | <Structure load='1a84' size='300' frame='true' align='right' caption='4uxq, insert caption here' scene='Insert optional scene name here' /> | ||
<scene name='48/483882/Green_scene1/1'>GreenScene</scene> | <scene name='48/483882/Green_scene1/1'>GreenScene</scene> | ||
| + | secondary structure with two key residues in the activation loop (highlighted in light blue) for Ponatinab binding | ||
| - | <Structure load='1a84' size='300' frame='true' align='right' caption='4uxq, secondary structure with two key residues in the activation loop (highlighted in light blue) for Ponatinab binding ' scene='Insert optional scene name here' /> | ||
<scene name='48/483882/Activation_loop/1'>Activation loop</scene> | <scene name='48/483882/Activation_loop/1'>Activation loop</scene> | ||
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==Binding Interactions== | ==Binding Interactions== | ||
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•To bind there must be a a conformational rearrangement of the conserved Asp630-Phe631-Gly632 (DFG) tripeptide motif at the proximal end of the activation loop<ref>PMID: 25465127</ref> | •To bind there must be a a conformational rearrangement of the conserved Asp630-Phe631-Gly632 (DFG) tripeptide motif at the proximal end of the activation loop<ref>PMID: 25465127</ref> | ||
| - | <Structure load='1a84' size='300' frame='true' align='right' caption='4uxq, Insert caption here' scene='Insert optional scene name here' /> | ||
<scene name='48/483882/4uxq/1'>Ligands SO4 and 0LI displayed</scene> | <scene name='48/483882/4uxq/1'>Ligands SO4 and 0LI displayed</scene> | ||
| + | FGFR4 active site for ponatinib binding with involved residues labeled | ||
| - | <Structure load='1a84' size='300' frame='true' align='right' caption='4uxq, FGFR4 active site for ponatinib binding with involved residues labeled' scene='Insert optional scene name here' /> | ||
<scene name='48/483882/Active_site/1'>Active Site for Ponatinib binding</scene> | <scene name='48/483882/Active_site/1'>Active Site for Ponatinib binding</scene> | ||
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==Additional Features== | ==Additional Features== | ||
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•Variant of FGFR-4 with (Arg(388)) replacing (Gly(388)) is associated with increased human prostate cancer. This causes increased receptor stability and activation. [2] | •Variant of FGFR-4 with (Arg(388)) replacing (Gly(388)) is associated with increased human prostate cancer. This causes increased receptor stability and activation. [2] | ||
| - | <Structure load='1a84' size='300' frame='true' align='right' caption='pdbcode, Insert caption here' scene='Insert optional scene name here' /> | ||
<scene name='48/483882/Hydrophobicity_and_residue_388/1'>Hydrophobicity and Residue 388</scene> | <scene name='48/483882/Hydrophobicity_and_residue_388/1'>Hydrophobicity and Residue 388</scene> | ||
| - | <br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br> | ||
==Quiz Question 1== | ==Quiz Question 1== | ||
Revision as of 21:49, 2 March 2016
| This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439. |
Fibroblast Growth Factor Receptor/Ponatinib (4uxq) [1]
by Julie Boshar, Emily Boyle, Nicole Kirby, Cory Thomas, Connor Walsh
Student Projects for UMass Chemistry 423 Spring 2016
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