Galactosidase
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | The <scene name='45/458439/Cv/3'>Zn+2 binding site is composed of 4 Cys residues</scene>. The <scene name='45/458439/Cv/5'>galactose binding site</scene> is seen in a <scene name='45/458439/Cv/6'>large central channel</scene><ref>PMID:12215416</ref>. | + | The <scene name='45/458439/Cv/3'>Zn+2 binding site is composed of 4 Cys residues</scene>. The <scene name='45/458439/Cv/5'>galactose binding site</scene> is seen in a <scene name='45/458439/Cv/6'>large central channel</scene><ref>PMID:12215416</ref>. Water molecules shown as red spheres. |
For [[3hg2]] <scene name='3hg2/3hg2to3morph/6'>click here to see cycling morph from empty active site to substrate bound form and back</scene>.<br /> | For [[3hg2]] <scene name='3hg2/3hg2to3morph/6'>click here to see cycling morph from empty active site to substrate bound form and back</scene>.<br /> | ||
Revision as of 12:57, 6 March 2016
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3D Structures of Galactosidase
Updated on 06-March-2016
References
- ↑ Garman SC, Garboczi DN. The molecular defect leading to Fabry disease: structure of human alpha-galactosidase. J Mol Biol. 2004 Mar 19;337(2):319-35. PMID:15003450 doi:10.1016/j.jmb.2004.01.035
- ↑ Jacobson RH, Zhang XJ, DuBose RF, Matthews BW. Three-dimensional structure of beta-galactosidase from E. coli. Nature. 1994 Jun 30;369(6483):761-6. PMID:8008071 doi:http://dx.doi.org/10.1038/369761a08015589
- ↑ Kint JA. Fabry's disease: alpha-galactosidase deficiency. Science. 1970 Feb 27;167(3922):1268-9. PMID:5411915
- ↑ Morrone A, Bardelli T, Donati MA, Giorgi M, Di Rocco M, Gatti R, Parini R, Ricci R, Taddeucci G, D'Azzo A, Zammarchi E. beta-galactosidase gene mutations affecting the lysosomal enzyme and the elastin-binding protein in GM1-gangliosidosis patients with cardiac involvement. Hum Mutat. 2000;15(4):354-66. PMID:10737981 doi:<354::AID-HUMU8>3.0.CO;2-L 10.1002/(SICI)1098-1004(200004)15:4<354::AID-HUMU8>3.0.CO;2-L
- ↑ Hidaka M, Fushinobu S, Ohtsu N, Motoshima H, Matsuzawa H, Shoun H, Wakagi T. Trimeric crystal structure of the glycoside hydrolase family 42 beta-galactosidase from Thermus thermophilus A4 and the structure of its complex with galactose. J Mol Biol. 2002 Sep 6;322(1):79-91. PMID:12215416
- Created with the participation of Wayne Decatur.
