Glucosamine 6-phosphate synthase
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='2vf5' size='350' side='right' caption='Structure of glucosamine 6-phosphate synthase complex with glucosamine-6-phosphate, sulfate and Na+ (purple) (PDB entry [[1moq]])' scene=''> |
| + | == Function == | ||
| - | '''Glucosamine 6-phosphate synthase''' (G6PS) catalyzes the first step in the biosynthesis of UDP-GlcNAc. G6PS converts fructose-6-phosphate (F6P) and glutamine to glucosamine-6-phosphate (G6P). N-acetylglucosamine is an essential building block of chitin which comprises the bacterial and fungal cell wall. Hence, G6PS is a target to anti-bacterial and anti-fungal agents. | + | '''Glucosamine 6-phosphate synthase''' (G6PS) catalyzes the first step in the biosynthesis of UDP-GlcNAc. G6PS converts fructose-6-phosphate (F6P) and glutamine to glucosamine-6-phosphate (G6P)<ref>PMID:8528769</ref>. The most potent inhibitor of G6PS is the intermediate analog amino-2-deoxy-D-glucitol 6-phosphate (ADGP). See also [[Isomerases]]. |
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| + | == Relevance == | ||
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| + | N-acetylglucosamine is an essential building block of chitin which comprises the bacterial and fungal cell wall. Hence, G6PS is a target to anti-bacterial and anti-fungal agents. | ||
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| + | == Structural highlights == | ||
==3D structures of glucosamine 6-phosphate synthase== | ==3D structures of glucosamine 6-phosphate synthase== | ||
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[[2bpl]] – EcG6PS + F6P<br /> | [[2bpl]] – EcG6PS + F6P<br /> | ||
[[2j6h]] - EcG6PS + oxo-norleucine + glucose 6-phosphate | [[2j6h]] - EcG6PS + oxo-norleucine + glucose 6-phosphate | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:58, 7 March 2016
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