This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Glucosamine 6-phosphate synthase
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | <StructureSection load=' | + | <StructureSection load='2vf5' size='350' side='right' caption='Structure of glucosamine 6-phosphate synthase complex with glucosamine-6-phosphate, sulfate and Na+ (purple) (PDB entry [[1moq]])' scene=''> |
| + | == Function == | ||
| - | '''Glucosamine 6-phosphate synthase''' (G6PS) catalyzes the first step in the biosynthesis of UDP-GlcNAc. G6PS converts fructose-6-phosphate (F6P) and glutamine to glucosamine-6-phosphate (G6P). N-acetylglucosamine is an essential building block of chitin which comprises the bacterial and fungal cell wall. Hence, G6PS is a target to anti-bacterial and anti-fungal agents. | + | '''Glucosamine 6-phosphate synthase''' (G6PS) catalyzes the first step in the biosynthesis of UDP-GlcNAc. G6PS converts fructose-6-phosphate (F6P) and glutamine to glucosamine-6-phosphate (G6P)<ref>PMID:8528769</ref>. The most potent inhibitor of G6PS is the intermediate analog amino-2-deoxy-D-glucitol 6-phosphate (ADGP). See also [[Isomerases]]. |
| + | |||
| + | == Relevance == | ||
| + | |||
| + | N-acetylglucosamine is an essential building block of chitin which comprises the bacterial and fungal cell wall. Hence, G6PS is a target to anti-bacterial and anti-fungal agents. | ||
| + | |||
| + | == Structural highlights == | ||
==3D structures of glucosamine 6-phosphate synthase== | ==3D structures of glucosamine 6-phosphate synthase== | ||
| Line 16: | Line 23: | ||
[[2bpl]] – EcG6PS + F6P<br /> | [[2bpl]] – EcG6PS + F6P<br /> | ||
[[2j6h]] - EcG6PS + oxo-norleucine + glucose 6-phosphate | [[2j6h]] - EcG6PS + oxo-norleucine + glucose 6-phosphate | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:58, 7 March 2016
| |||||||||||
