Glutaminase
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_3unw| PDB=3unw | SIZE=400| SCENE= |right|CAPTION=Human glutaminase tetramer complex with glutamate [[3unw]] }} | {{STRUCTURE_3unw| PDB=3unw | SIZE=400| SCENE= |right|CAPTION=Human glutaminase tetramer complex with glutamate [[3unw]] }} | ||
| - | + | == Function == | |
| - | '''Glutaminase''' (GLN) catalyzes the conversion of glutamine (Gln) to glutamic acid (Glu). GLN is present at the axonal termini of neurons where GA functions as a neurotransmitter. ADP is an activator of GLN. GLN is a homodimer. In human GLN is found as 2 isozymes – GLN and GLN 2. Glutaminase-asparaginase (GLN-ASN) can amidohydrolase both glutamine and asparagine to their corresponding Glu and Asp. | + | '''Glutaminase''' (GLN) catalyzes the conversion of glutamine (Gln) to glutamic acid (Glu). GLN is present at the axonal termini of neurons where GA functions as a neurotransmitter. ADP is an activator of GLN. GLN is a homodimer<ref>PMID:11533299</ref>. In human GLN is found as 2 isozymes – GLN and GLN 2. '''Glutaminase-asparaginase''' (GLN-ASN) can amidohydrolase both glutamine and asparagine to their corresponding Glu and Asp<ref>PMID:6838661</ref>. |
==3D structures of glutaminase== | ==3D structures of glutaminase== | ||
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**[[1mki]] - YbgJ free <br /> | **[[1mki]] - YbgJ free <br /> | ||
}} | }} | ||
| - | + | == References == | |
| + | <references/> | ||
Created with the participation of [[User:Lindsey Butler|Lindsey Butler]]. | Created with the participation of [[User:Lindsey Butler|Lindsey Butler]]. | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 11:05, 8 March 2016
Function
Glutaminase (GLN) catalyzes the conversion of glutamine (Gln) to glutamic acid (Glu). GLN is present at the axonal termini of neurons where GA functions as a neurotransmitter. ADP is an activator of GLN. GLN is a homodimer[1]. In human GLN is found as 2 isozymes – GLN and GLN 2. Glutaminase-asparaginase (GLN-ASN) can amidohydrolase both glutamine and asparagine to their corresponding Glu and Asp[2].
3D structures of glutaminase
Updated on 08-March-2016
References
- ↑ Curthoys NP. Role of mitochondrial glutaminase in rat renal glutamine metabolism. J Nutr. 2001 Sep;131(9 Suppl):2491S-5S; discussion 2496S-7S. PMID:11533299
- ↑ Steckel J, Roberts J, Philips FS, Chou TC. Kinetic properties and inhibition of Acinetobacter glutaminase-asparaginase. Biochem Pharmacol. 1983 Mar 15;32(6):971-7. PMID:6838661
Created with the participation of Lindsey Butler.
