Glutaminyl cyclase
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='2afu' size='340' side='right' caption='Structure of humany glutaminyl cyclase complex with inhibitor (PDB code [[3pbb]]).' scene=''> |
== Function == | == Function == | ||
| - | '''Glutaminyl cyclase''' (QC) catalyzes the conversion of glutaminyl-peptide to 5-oxoprolyl-peptide and ammonia. Thus QC catalyzes the cyclization of an N-terminal glutamyl residue. | + | '''Glutaminyl cyclase''' (QC) catalyzes the conversion of glutaminyl-peptide to 5-oxoprolyl-peptide and ammonia. Thus QC catalyzes the cyclization of an N-terminal glutamyl residue<ref>PMID:3597387</ref>. |
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== Relevance == | == Relevance == | ||
| - | QC is considered as a marker of thyroid tumors. | + | QC is considered as a marker of thyroid tumors. QC acts on the generation of N-terminal pyroglutamyl groups of peptide hormones and amyloid-related plaque-forming peptides. The latter contributes to Alzheimer disease. Alzheimer patients show increased expression of QC<ref>PMID:23207485</ref> and QC inhibitors reduces the disease pathology and symptoms. |
== Structural highlights == | == Structural highlights == | ||
Revision as of 11:24, 9 March 2016
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3D Structures of glutaminyl cyclase
Updated on 09-March-2016
References
- ↑ Busby WH Jr, Quackenbush GE, Humm J, Youngblood WW, Kizer JS. An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes. J Biol Chem. 1987 Jun 25;262(18):8532-6. PMID:3597387
- ↑ Valenti MT, Bolognin S, Zanatta C, Donatelli L, Innamorati G, Pampanin M, Zanusso G, Zatta P, Dalle Carbonare L. Increased glutaminyl cyclase expression in peripheral blood of Alzheimer's disease patients. J Alzheimers Dis. 2013;34(1):263-71. doi: 10.3233/JAD-120517. PMID:23207485 doi:http://dx.doi.org/10.3233/JAD-120517
