5frs
From Proteopedia
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/PDS5_YEAST PDS5_YEAST]] Essential for the establishment and maintenance of sister chromatid cohesion at centromere proximal and distal regions during S phase. Also required for chromosomal condensation.<ref>PMID:11062262</ref> <ref>PMID:11137006</ref> [[http://www.uniprot.org/uniprot/SCC1_YEAST SCC1_YEAST]] Cleavable component of the cohesin complex involved in chromosome cohesion during cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by ESP1 and dissociates from chromatin, allowing sister chromatids to segregate.<ref>PMID:9335333</ref> <ref>PMID:9335334</ref> <ref>PMID:9491073</ref> <ref>PMID:10403247</ref> | [[http://www.uniprot.org/uniprot/PDS5_YEAST PDS5_YEAST]] Essential for the establishment and maintenance of sister chromatid cohesion at centromere proximal and distal regions during S phase. Also required for chromosomal condensation.<ref>PMID:11062262</ref> <ref>PMID:11137006</ref> [[http://www.uniprot.org/uniprot/SCC1_YEAST SCC1_YEAST]] Cleavable component of the cohesin complex involved in chromosome cohesion during cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by ESP1 and dissociates from chromatin, allowing sister chromatids to segregate.<ref>PMID:9335333</ref> <ref>PMID:9335334</ref> <ref>PMID:9491073</ref> <ref>PMID:10403247</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Sister chromatid cohesion is a fundamental prerequisite to faithful genome segregation. Cohesion is precisely regulated by accessory factors that modulate the stability with which the cohesin complex embraces chromosomes. One of these factors, Pds5, engages cohesin through Scc1 and is both a facilitator of cohesion, and, conversely also mediates the release of cohesin from chromatin. We present here the crystal structure of a complex between budding yeast Pds5 and Scc1, thus elucidating the molecular basis of Pds5 function. Pds5 forms an elongated HEAT repeat that binds to Scc1 via a conserved surface patch. We demonstrate that the integrity of the Pds5-Scc1 interface is indispensable for the recruitment of Pds5 to cohesin, and that its abrogation results in loss of sister chromatid cohesion and cell viability. | ||
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| + | Structure of the Pds5-Scc1 Complex and Implications for Cohesin Function.,Muir KW, Kschonsak M, Li Y, Metz J, Haering CH, Panne D Cell Rep. 2016 Feb 24. pii: S2211-1247(16)30094-8. doi:, 10.1016/j.celrep.2016.01.078. PMID:26923589<ref>PMID:26923589</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5frs" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 19:37, 9 March 2016
Structure of the Pds5-Scc1 complex and implications for cohesin function
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Categories: Saccharomyces cerevisiae | Haering, C H | Kschonsak, M | Li, Y | Metz, J | Muir, K W | Panne, D | Cell cycle | Cohesin | Dna replication | Pds5 | Scc1 | Sister chromatid cohesion | Smc1 | Smc3 | Wapl
