5chl
From Proteopedia
(Difference between revisions)
Line 1: | Line 1: | ||
- | '''Unreleased structure''' | ||
- | + | ==Structural basis of H2A.Z recognition by YL1 histone chaperone component of SRCAP/SWR1 chromatin remodeling complex== | |
- | + | <StructureSection load='5chl' size='340' side='right' caption='[[5chl]], [[Resolution|resolution]] 1.89Å' scene=''> | |
- | + | == Structural highlights == | |
- | + | <table><tr><td colspan='2'>[[5chl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CHL FirstGlance]. <br> | |
- | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5chl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5chl OCA], [http://pdbe.org/5chl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5chl RCSB], [http://www.ebi.ac.uk/pdbsum/5chl PDBsum]</span></td></tr> | |
- | [[Category: | + | </table> |
+ | == Function == | ||
+ | [[http://www.uniprot.org/uniprot/VPS72_DROME VPS72_DROME]] Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV.<ref>PMID:15528408</ref> <ref>PMID:16299513</ref> [[http://www.uniprot.org/uniprot/H2AZ_HUMAN H2AZ_HUMAN]] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.<ref>PMID:15878876</ref> | ||
+ | == References == | ||
+ | <references/> | ||
+ | __TOC__ | ||
+ | </StructureSection> | ||
+ | [[Category: Liang, X]] | ||
+ | [[Category: Pan, L]] | ||
+ | [[Category: Shan, S]] | ||
[[Category: Wu, C]] | [[Category: Wu, C]] | ||
- | [[Category: Shan, S]] | ||
- | [[Category: Pan, L]] | ||
- | [[Category: Liang, X]] | ||
[[Category: Zhou, Z]] | [[Category: Zhou, Z]] | ||
+ | [[Category: Chaperone]] | ||
+ | [[Category: Histone]] | ||
+ | [[Category: Remodeling complex]] |
Revision as of 03:53, 10 March 2016
Structural basis of H2A.Z recognition by YL1 histone chaperone component of SRCAP/SWR1 chromatin remodeling complex
|
Categories: Liang, X | Pan, L | Shan, S | Wu, C | Zhou, Z | Chaperone | Histone | Remodeling complex