5chl

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'''Unreleased structure'''
 
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The entry 5chl is ON HOLD until Paper Publication
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==Structural basis of H2A.Z recognition by YL1 histone chaperone component of SRCAP/SWR1 chromatin remodeling complex==
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<StructureSection load='5chl' size='340' side='right' caption='[[5chl]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
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Authors: Shan, S., Liang, X., Pan, L., Wu, C., Zhou, Z.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5chl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CHL FirstGlance]. <br>
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Description:
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5chl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5chl OCA], [http://pdbe.org/5chl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5chl RCSB], [http://www.ebi.ac.uk/pdbsum/5chl PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/VPS72_DROME VPS72_DROME]] Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV.<ref>PMID:15528408</ref> <ref>PMID:16299513</ref> [[http://www.uniprot.org/uniprot/H2AZ_HUMAN H2AZ_HUMAN]] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.<ref>PMID:15878876</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Liang, X]]
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[[Category: Pan, L]]
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[[Category: Shan, S]]
[[Category: Wu, C]]
[[Category: Wu, C]]
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[[Category: Shan, S]]
 
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[[Category: Pan, L]]
 
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[[Category: Liang, X]]
 
[[Category: Zhou, Z]]
[[Category: Zhou, Z]]
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[[Category: Chaperone]]
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[[Category: Histone]]
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[[Category: Remodeling complex]]

Revision as of 03:53, 10 March 2016

Structural basis of H2A.Z recognition by YL1 histone chaperone component of SRCAP/SWR1 chromatin remodeling complex

5chl, resolution 1.89Å

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