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5ex0
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human SMYD3 in complex with a MAP3K2 peptide== | |
| - | + | <StructureSection load='5ex0' size='340' side='right' caption='[[5ex0]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ex0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EX0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EX0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ex3|5ex3]]</td></tr> |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ex0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ex0 OCA], [http://pdbe.org/5ex0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ex0 RCSB], [http://www.ebi.ac.uk/pdbsum/5ex0 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SMYD3_HUMAN SMYD3_HUMAN]] Histone methyltransferase. Specifically methylates 'Lys-4' and 'Lys-5' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences.<ref>PMID:15235609</ref> <ref>PMID:22419068</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Histone-lysine N-methyltransferase]] | ||
| + | [[Category: Fu, W]] | ||
[[Category: Liu, N]] | [[Category: Liu, N]] | ||
| - | [[Category: Fu, W]] | ||
| - | [[Category: Xu, R.M]] | ||
[[Category: Min, J]] | [[Category: Min, J]] | ||
[[Category: Qiao, Q]] | [[Category: Qiao, Q]] | ||
| + | [[Category: Wang, M]] | ||
| + | [[Category: Xu, R M]] | ||
[[Category: Yang, N]] | [[Category: Yang, N]] | ||
[[Category: Zhu, B]] | [[Category: Zhu, B]] | ||
| + | [[Category: Cancer]] | ||
| + | [[Category: Chromatin]] | ||
| + | [[Category: Methylation]] | ||
| + | [[Category: Set domain]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 03:56, 10 March 2016
Crystal structure of human SMYD3 in complex with a MAP3K2 peptide
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Categories: Histone-lysine N-methyltransferase | Fu, W | Liu, N | Min, J | Qiao, Q | Wang, M | Xu, R M | Yang, N | Zhu, B | Cancer | Chromatin | Methylation | Set domain | Transferase
