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5fug
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of a human YL1-H2A.Z-H2B complex== | |
| - | + | <StructureSection load='5fug' size='340' side='right' caption='[[5fug]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5fug]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FUG FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fue|5fue]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fug OCA], [http://pdbe.org/5fug PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fug RCSB], [http://www.ebi.ac.uk/pdbsum/5fug PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/H2AZ_HUMAN H2AZ_HUMAN]] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.<ref>PMID:15878876</ref> [[http://www.uniprot.org/uniprot/VPS72_HUMAN VPS72_HUMAN]] Could be a DNA-binding transcriptional regulator. May be involved in chromatin modification and remodeling. [[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dimitrov, S]] | ||
| + | [[Category: Ennifar, E]] | ||
| + | [[Category: Hamiche, A]] | ||
| + | [[Category: Ignatyeva, M]] | ||
| + | [[Category: Latrick, C M]] | ||
| + | [[Category: Marek, M]] | ||
| + | [[Category: Obri, A]] | ||
| + | [[Category: Ouararhni, K]] | ||
| + | [[Category: Papin, C]] | ||
[[Category: Romier, C]] | [[Category: Romier, C]] | ||
| - | [[Category: | + | [[Category: Stoll, I]] |
| + | [[Category: Chaperone]] | ||
| + | [[Category: Dna binding protein]] | ||
| + | [[Category: H2a z]] | ||
| + | [[Category: Histone]] | ||
| + | [[Category: Remodeler]] | ||
| + | [[Category: Yl1]] | ||
Revision as of 03:57, 10 March 2016
Crystal structure of a human YL1-H2A.Z-H2B complex
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Categories: Dimitrov, S | Ennifar, E | Hamiche, A | Ignatyeva, M | Latrick, C M | Marek, M | Obri, A | Ouararhni, K | Papin, C | Romier, C | Stoll, I | Chaperone | Dna binding protein | H2a z | Histone | Remodeler | Yl1
