5fv9
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of GalNAc-T2 in complex with compound 16d== | |
| - | + | <StructureSection load='5fv9' size='340' side='right' caption='[[5fv9]], [[Resolution|resolution]] 2.07Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5fv9]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FV9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FV9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene>, <scene name='pdbligand=Y6W:[(2R,3S,4R,5R)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+HYDROGEN+(S)-{3-[(2R,3R,4R,5R,6R)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2-YL]PROPYL}PHOSPHONATE'>Y6W</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fv9 OCA], [http://pdbe.org/5fv9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fv9 RCSB], [http://www.ebi.ac.uk/pdbsum/5fv9 PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GALT2_HUMAN GALT2_HUMAN]] Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region.<ref>PMID:9295285</ref> <ref>PMID:12438318</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Delso, I]] | ||
| + | [[Category: Ghirardello, M]] | ||
| + | [[Category: Hurtado-Guerrero, R]] | ||
[[Category: Lacetera, A]] | [[Category: Lacetera, A]] | ||
[[Category: Martin-Santamaria, S]] | [[Category: Martin-Santamaria, S]] | ||
| + | [[Category: Merino, P]] | ||
| + | [[Category: Navarrete, E Lira-]] | ||
[[Category: Rivas, M]] | [[Category: Rivas, M]] | ||
| - | [[Category: Delso, I]] | ||
[[Category: Tejero, T]] | [[Category: Tejero, T]] | ||
| - | [[Category: | + | [[Category: Transferase]] |
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Revision as of 03:58, 10 March 2016
Crystal structure of GalNAc-T2 in complex with compound 16d
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