5hdt

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'''Unreleased structure'''
 
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The entry 5hdt is ON HOLD until Paper Publication
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==Human cohesin regulator Pds5B bound to a Wapl peptide==
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<StructureSection load='5hdt' size='340' side='right' caption='[[5hdt]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
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Authors: Ouyang, Z., Tomchick, D.R., Yu, H.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5hdt]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HDT FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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[[Category: Tomchick, D.R]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hdt OCA], [http://pdbe.org/5hdt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hdt RCSB], [http://www.ebi.ac.uk/pdbsum/5hdt PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PDS5B_HUMAN PDS5B_HUMAN]] Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.<ref>PMID:10963680</ref> <ref>PMID:15855230</ref> <ref>PMID:19696148</ref> [[http://www.uniprot.org/uniprot/WAPL_HUMAN WAPL_HUMAN]] Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.<ref>PMID:15150110</ref> <ref>PMID:17113138</ref> <ref>PMID:17112726</ref> <ref>PMID:19696148</ref> <ref>PMID:19907496</ref> <ref>PMID:21111234</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Ouyang, Z]]
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[[Category: Tomchick, D R]]
[[Category: Yu, H]]
[[Category: Yu, H]]
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[[Category: Ouyang, Z]]
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[[Category: Cell cycle]]
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[[Category: Cohesin regulator]]
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[[Category: Ip6]]
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[[Category: Pds5b]]
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[[Category: Wapl]]

Revision as of 03:58, 10 March 2016

Human cohesin regulator Pds5B bound to a Wapl peptide

5hdt, resolution 2.71Å

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