This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5i3o
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor== | |
| - | + | <StructureSection load='5i3o' size='340' side='right' caption='[[5i3o]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5i3o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I3O FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IDV:N-(6-{3-[(DIMETHYLSULFAMOYL)AMINO]PHENYL}-1H-INDAZOL-3-YL)CYCLOPROPANECARBOXAMIDE'>IDV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4w9w|4w9w]], [[4w9x|4w9x]], [[5i3r|5i3r]]</td></tr> |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i3o OCA], [http://pdbe.org/5i3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i3o RCSB], [http://www.ebi.ac.uk/pdbsum/5i3o PDBsum]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BMP2K_HUMAN BMP2K_HUMAN]] May be involved in osteoblast differentiation. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Non-specific serine/threonine protein kinase]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Arruda, P]] | ||
| + | [[Category: Axtman, A]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
| - | [[Category: | + | [[Category: Counago, R M]] |
| - | [[Category: | + | [[Category: Drewry, D]] |
| - | [[Category: Edwards, A | + | [[Category: Edwards, A M]] |
| - | [[Category: | + | [[Category: Elkins, J M]] |
[[Category: Gileadi, O]] | [[Category: Gileadi, O]] | ||
| - | [[Category: | + | [[Category: Krojer, T]] |
| - | [[Category: Structural | + | [[Category: Structural genomic]] |
| + | [[Category: Savitsky, P]] | ||
| + | [[Category: Sorrell, F J]] | ||
| + | [[Category: Wells, C]] | ||
| + | [[Category: Willson, T M]] | ||
| + | [[Category: Zhang, C]] | ||
| + | [[Category: Zuercher, W]] | ||
| + | [[Category: Protein kinase domain]] | ||
| + | [[Category: Sgc]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 04:00, 10 March 2016
Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor
| |||||||||||
Categories: Non-specific serine/threonine protein kinase | Arrowsmith, C H | Arruda, P | Axtman, A | Bountra, C | Counago, R M | Drewry, D | Edwards, A M | Elkins, J M | Gileadi, O | Krojer, T | Structural genomic | Savitsky, P | Sorrell, F J | Wells, C | Willson, T M | Zhang, C | Zuercher, W | Protein kinase domain | Sgc | Transferase | Transferase-transferase inhibitor complex
