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Glycerate kinase
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{{STRUCTURE_1to6| PDB=1to6 | SIZE=400| SCENE=Glycerate_kinase/Glycerate_kinase/1|right|CAPTION=Glycerate kinase dimer complex with SO4 ions, [[1to6]] }} | {{STRUCTURE_1to6| PDB=1to6 | SIZE=400| SCENE=Glycerate_kinase/Glycerate_kinase/1|right|CAPTION=Glycerate kinase dimer complex with SO4 ions, [[1to6]] }} | ||
| - | + | == Function == | |
'''Glycerate kinase''' (GK) catalyzes the conversion of ATP + glycerate to ADP + 3-phospho-glycerate. GK participates in the metabolic pathways of serine/glycine/threonine, glycolipid and glyoxylate-dicarboxylate. GK is the last step in the pathway which starts with glucose and ends with 2-phosphoglycerate<ref>PMID:5325263</ref>. | '''Glycerate kinase''' (GK) catalyzes the conversion of ATP + glycerate to ADP + 3-phospho-glycerate. GK participates in the metabolic pathways of serine/glycine/threonine, glycolipid and glyoxylate-dicarboxylate. GK is the last step in the pathway which starts with glucose and ends with 2-phosphoglycerate<ref>PMID:5325263</ref>. | ||
| + | |||
| + | == Disease == | ||
| + | Mutation in GK is the cause of inherited D-glyceric acidemia) (D-glyceric aciduria)<ref>PMID:20949620</ref>. | ||
== 3D Structures of glycerate kinase == | == 3D Structures of glycerate kinase == | ||
Revision as of 07:30, 13 March 2016
Contents |
Function
Glycerate kinase (GK) catalyzes the conversion of ATP + glycerate to ADP + 3-phospho-glycerate. GK participates in the metabolic pathways of serine/glycine/threonine, glycolipid and glyoxylate-dicarboxylate. GK is the last step in the pathway which starts with glucose and ends with 2-phosphoglycerate[1].
Disease
Mutation in GK is the cause of inherited D-glyceric acidemia) (D-glyceric aciduria)[2].
3D Structures of glycerate kinase
Updated on 13-March-2016
1to6 – GK – Neisseria meningitides
References
- ↑ Doughty CC, Hayashi JA, Guenther HL. Purification and properties of D-glycerate 3-kinase from Escherichia coli. J Biol Chem. 1966 Feb 10;241(3):568-72. PMID:5325263
- ↑ Sass JO, Fischer K, Wang R, Christensen E, Scholl-Burgi S, Chang R, Kapelari K, Walter M. D-glyceric aciduria is caused by genetic deficiency of D-glycerate kinase (GLYCTK). Hum Mutat. 2010 Dec;31(12):1280-5. doi: 10.1002/humu.21375. Epub 2010 Nov 9. PMID:20949620 doi:http://dx.doi.org/10.1002/humu.21375
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