Glycerol kinase
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | {{STRUCTURE_1r59| PDB=1r59 | SIZE=400| SCENE= |right| CAPTION=Glycerol kinase dimer [[1r59]] }} | ||
| - | < | + | <StructureSection load='1xup' size='350' side='right' caption='Human α-defensin 1 (PDB entry [[2pm4]])' scene=''> |
| - | + | == Function == | |
| - | + | '''Glycerol kinase''' (GK) phosphorylates glycerol forming glycerol 3-phosphate (G3P) using Mg-ATP as phosphate source. GK is a key enzyme in glycerol uptake and metabolism. Mutations of GK gene cause GK deficiency syndrome. PK is a multi-subunit allosteric enzyme. Its activity can be inhibited by fructose 1,6-bisphosphate (FBP) and by the glucose-specific phosphocarrier IIA(Glc). PK cofactor is a Zn atom which binds to the dimer<ref>PMID:8528769</ref>. | |
| - | + | ||
| - | + | ||
| - | '''Glycerol kinase''' (GK) phosphorylates glycerol forming glycerol 3-phosphate (G3P) using Mg-ATP as phosphate source. GK is a key enzyme in glycerol uptake and metabolism. Mutations of GK gene cause GK deficiency syndrome. PK is a multi-subunit allosteric enzyme. Its activity can be inhibited by fructose 1,6-bisphosphate (FBP) and by the glucose-specific phosphocarrier IIA(Glc). PK cofactor is a Zn atom which binds to the dimer. | + | |
==3D structures of glycerol kinase== | ==3D structures of glycerol kinase== | ||
| Line 46: | Line 42: | ||
**[[3wxl]] – TbGK + glycerol + ADP<br /> | **[[3wxl]] – TbGK + glycerol + ADP<br /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 07:45, 13 March 2016
| |||||||||||
