Glyoxalase
From Proteopedia
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{{STRUCTURE_1qin| PDB=1qin | SIZE=400| SCENE= |right|CAPTION=Human glyoxalase I dimer complex with glutathione derivative and Zn+2 ion, [[1qin]] }} | {{STRUCTURE_1qin| PDB=1qin | SIZE=400| SCENE= |right|CAPTION=Human glyoxalase I dimer complex with glutathione derivative and Zn+2 ion, [[1qin]] }} | ||
| - | + | == Function == | |
| - | '''Glyoxalase''' (GLO) is part of glyoxalase system which detoxify the highly toxic methylglyoxal and other aldehydes produced by metabolism. <br /> | + | '''Glyoxalase''' (GLO) is part of glyoxalase system which detoxify the highly toxic methylglyoxal and other aldehydes produced by metabolism<ref>PMID:10066594</ref>. <br /> |
* '''GLO1''' catalyzes the conversion of glutathione and methylglyoxal to lactoylglutathione.<br /> | * '''GLO1''' catalyzes the conversion of glutathione and methylglyoxal to lactoylglutathione.<br /> | ||
| - | * | + | * '''GLO2''' is a metalloenzyme which catalyzes the hydrolysis of lactoylglutathione to glutathione and lactate. GLO2 exists as cytosolic and mitochondrial forms. For details on GLO2 see [[Leishmania infantum Glyoxalase II]]. |
| + | |||
| + | == Relevance == | ||
| + | GLO1 is a target for drugs against bacteria, protozoans and cancer<ref>PMID:8277832</ref>. | ||
==3D structures of glyoxalase== | ==3D structures of glyoxalase== | ||
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**[[4lru]] – GLO – ''Candida albicans''<br /> | **[[4lru]] – GLO – ''Candida albicans''<br /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:41, 15 March 2016
Contents |
Function
Glyoxalase (GLO) is part of glyoxalase system which detoxify the highly toxic methylglyoxal and other aldehydes produced by metabolism[1].
- GLO1 catalyzes the conversion of glutathione and methylglyoxal to lactoylglutathione.
- GLO2 is a metalloenzyme which catalyzes the hydrolysis of lactoylglutathione to glutathione and lactate. GLO2 exists as cytosolic and mitochondrial forms. For details on GLO2 see Leishmania infantum Glyoxalase II.
Relevance
GLO1 is a target for drugs against bacteria, protozoans and cancer[2].
3D structures of glyoxalase
Updated on 15-March-2016
References
- ↑ Dixon DP, Cummins L, Cole DJ, Edwards R. Glutathione-mediated detoxification systems in plants. Curr Opin Plant Biol. 1998 Jun;1(3):258-66. PMID:10066594
- ↑ Thornalley PJ. The glyoxalase system in health and disease. Mol Aspects Med. 1993;14(4):287-371. PMID:8277832
