Glutaryl-CoA dehydrogenase

Function

Glutaryl-CoA dehydrogenase (GCD) converts glutaryl-CoA to crotonyl-CoA. GCD is part of the metabolism of lysine and tryptophan^[1].

Disease

Defective GCD causes the often fatal glutaric acidemia^[2]. The active GCD is a tetramer. Mutations which result in GCD dimers or monomers are associated with glutaric acidemia.

Structural highlights

The bilogical assembly of GCD from Desulfococcus multivorans is . GCD active site is in a cleft formed by its α,β,α domains^[3].

3D structures of glutaryl-CoA dehydrogenase

Updated on 15-March-2016

3d6b, 3eom, 3ii9 – BpGCD – Burkholderia pseudomallei

3eon – BpGCD + difluorophenyl methanol
3gqt – BpGCD + quinoxaline derivative
3gnc – BpGCD + piperazine derivative
3mpi – DmGCD + FAD + glutaryl-CoA – Desulfococcus multivorans
3mpj – DmGCD + FAD + peptide
1siq, 1sir – hGCD + FAD - human
2r0m – hGCD (mutant) + FAD + dienolate intermediate
2r0n – hGCD (mutant) + FAD + thiaglutarate-CoA
3sf6, 3swo – GCD + FDA – Mycobacterium smegmatis

References

1. ↑ Rao KS, Albro M, Dwyer TM, Frerman FE. Kinetic mechanism of glutaryl-CoA dehydrogenase. Biochemistry. 2006 Dec 26;45(51):15853-61. Epub 2006 Dec 2. PMID:17176108 doi:http://dx.doi.org/10.1021/bi0609016
2. ↑ . PMID:249723495
3. ↑ Wischgoll S, Demmer U, Warkentin E, Gunther R, Boll M, Ermler U. Structural basis for promoting and preventing decarboxylation in glutaryl-coenzyme a dehydrogenases. Biochemistry. 2010 Jun 29;49(25):5350-7. PMID:20486657 doi:10.1021/bi100317m