Granzyme
From Proteopedia
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<StructureSection load='1fq3' size='400' side='right' caption='Structure of glycosylated human granzyme B dimer complex with sulfate (PDB entry [[1fq3]])' scene=''> | <StructureSection load='1fq3' size='400' side='right' caption='Structure of glycosylated human granzyme B dimer complex with sulfate (PDB entry [[1fq3]])' scene=''> | ||
| - | '''Granzymes''' (GZM) are serine proteases which induce apoptosis in virus-infected cells. | + | '''Granzymes''' (GZM) are serine proteases which induce apoptosis in virus-infected cells<ref>PMID:17158907</ref>.<br /> |
| + | *'''Granzyme A and K''' is the most abundant serine protease in killer cells cytotoxic granules <ref>PMID:20536557</ref>.<br /> | ||
| + | *'''Granzyme B and C''' induces cytotoxic T lymphocyte-mediated target cell apoptosis <ref>PMID:12752668</ref>.<br /> | ||
| + | *'''Granzyme H''' helps granzyme B kill adenovirus-infected cells <ref>PMID:17766182</ref>.<br /> | ||
| + | *'''Granzyme M''' induces target cell death, inhibits viral replication and regulates inflammation <ref>PMID:24413154</ref>.<br /> | ||
</StructureSection> | </StructureSection> | ||
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**[[2zgj]] – hGZM (mutant) + polypeptide<br /> | **[[2zgj]] – hGZM (mutant) + polypeptide<br /> | ||
}} | }} | ||
| - | + | == References == | |
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:35, 16 March 2016
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3D structures of granzyme
Updated on 16-March-2016
References
- ↑ Bots M, Medema JP. Granzymes at a glance. J Cell Sci. 2006 Dec 15;119(Pt 24):5011-4. PMID:17158907 doi:http://dx.doi.org/10.1242/jcs.03239
- ↑ Lieberman J. Granzyme A activates another way to die. Immunol Rev. 2010 May;235(1):93-104. doi: 10.1111/j.0105-2896.2010.00902.x. PMID:20536557 doi:http://dx.doi.org/10.1111/j.0105-2896.2010.00902.x
- ↑ Lord SJ, Rajotte RV, Korbutt GS, Bleackley RC. Granzyme B: a natural born killer. Immunol Rev. 2003 Jun;193:31-8. PMID:12752668
- ↑ Waterhouse NJ, Trapani JA. H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells. Trends Immunol. 2007 Sep;28(9):373-5. Epub 2007 Sep 4. PMID:17766182 doi:http://dx.doi.org/10.1016/j.it.2007.08.001
- ↑ de Poot SA, Bovenschen N. Granzyme M: behind enemy lines. Cell Death Differ. 2014 Mar;21(3):359-68. doi: 10.1038/cdd.2013.189. Epub 2014, Jan 10. PMID:24413154 doi:http://dx.doi.org/10.1038/cdd.2013.189
