Gramicidin

From Proteopedia

Revision as of 11:10, 16 March 2016

spinqualitylabelsall models Gramicidin A complex with thiocyanate and K+ ion (PDB entry 1gmk) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Relevance 3 Structural highlights 3.1 Gramicidin A Function Gramicidin (GCDN) is a polypeptide composed of alternating L- and D-amino acids. It is produced by the bacteria Bacillus brevis[1]. GCDN S is an antibiotic cyclic polypeptide. GCDN D is a mixture of GCDN A, B, C. See theoretical model of Gramicidin Channel in Lipid Bilayer. Relevance GCDN has bactericidal activity and is used as a topical antibiotic and as topical contraceptive[2]. Structural highlights Gramicidin A Ligands:

3D Structures of Gramicidin

Updated on 16-March-2016

References

1. ↑ Urry DW, Goodall MC, Glickson JD, Mayers DF. The gramicidin A transmembrane channel: characteristics of head-to-head dimerized (L,D) helices. Proc Natl Acad Sci U S A. 1971 Aug;68(8):1907-11. PMID:5288776
2. ↑ Kondejewski LH, Farmer SW, Wishart DS, Hancock RE, Hodges RS. Gramicidin S is active against both gram-positive and gram-negative bacteria. Int J Pept Protein Res. 1996 Jun;47(6):460-6. PMID:8836773