User:John S. de Banzie/Sandbox 4
From Proteopedia
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==Yeast U4/U6.U5 tri-snRNP== | ==Yeast U4/U6.U5 tri-snRNP== | ||
<StructureSection load='5gan' size='640' side='right' caption='U4/U6.U5 snRNP' [[5gan]]' scene='72/726441/Firstscene/2'> | <StructureSection load='5gan' size='640' side='right' caption='U4/U6.U5 snRNP' [[5gan]]' scene='72/726441/Firstscene/2'> | ||
| - | The <scene='72/726441/Firstscene/2'>initial view</scene> shows proteins in white and the three snRNAs in colour (U4, U5, and U6). | + | The <scene name='72/726441/Firstscene/2'>initial view</scene> shows proteins in white and the three snRNAs in colour (U4, U5, and U6). |
| - | <scene='72/726441/Rnascene/1'> | + | Focusing <scene name='72/726441/Rnascene/1'>on the RNAs</scene> reveals extensive base pairing between the U4 and U6 snRNAs. |
| - | The U2 snRNP binds to the region highlighted in blue in this view. The U1 snRNP binds to the U2snRNP. Both interactions lead to extensive conformational change and activation of the spliceosome. | + | The U2 snRNP <scene name='72/726441/Dockscene/1'>binds to the region </scene>highlighted in blue in this view. The U1 snRNP binds to the U2snRNP. Both interactions lead to extensive conformational change and activation of the spliceosome. |
For the source article see Nguyen et al, 2016<ref>DOI 10.1038/nature16940</ref>. | For the source article see Nguyen et al, 2016<ref>DOI 10.1038/nature16940</ref>. | ||
Revision as of 15:23, 18 March 2016
Yeast U4/U6.U5 tri-snRNP
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References
- ↑ Nguyen TH, Galej WP, Bai XC, Oubridge C, Newman AJ, Scheres SH, Nagai K. Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 A resolution. Nature. 2016 Feb 18;530(7590):298-302. doi: 10.1038/nature16940. Epub 2016 Feb 1. PMID:26829225 doi:http://dx.doi.org/10.1038/nature16940
