User:John S. de Banzie/Sandbox 4

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The <scene name='72/726441/Firstscene/2'>initial view</scene> shows proteins in white and the three snRNAs in colour (U4, U5, and U6).
The <scene name='72/726441/Firstscene/2'>initial view</scene> shows proteins in white and the three snRNAs in colour (U4, U5, and U6).
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Focusing <scene name='72/726441/Rnascene/1'>on the RNAs</scene> reveals extensive base pairing between the U4 and U6 snRNAs.
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Focusing <scene name='72/726441/Rnascene/1'>on the RNAs</scene> reveals secondary structure and extensive base pairing between the U4 and U6 snRNAs.
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The U2 snRNP <scene name='72/726441/Dockscene/1'>binds to the region </scene>highlighted in blue in this view. The U1 snRNP binds to the U2snRNP. Both interactions lead to extensive conformational change and activation of the spliceosome.
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The U2 snRNP <scene name='72/726441/Dockscene/1'>binds to the region</scene> highlighted in blue in this view. The U1 snRNP binds to the U2 snRNP. Both interactions lead to extensive conformational change and activation of the spliceosome.
For the source article see Nguyen et al, 2016<ref>DOI 10.1038/nature16940</ref>.
For the source article see Nguyen et al, 2016<ref>DOI 10.1038/nature16940</ref>.
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
 
</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
<references/>

Revision as of 15:26, 18 March 2016

Yeast U4/U6.U5 tri-snRNP

U4/U6.U5 snRNP

Drag the structure with the mouse to rotate

References

  1. Nguyen TH, Galej WP, Bai XC, Oubridge C, Newman AJ, Scheres SH, Nagai K. Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 A resolution. Nature. 2016 Feb 18;530(7590):298-302. doi: 10.1038/nature16940. Epub 2016 Feb 1. PMID:26829225 doi:http://dx.doi.org/10.1038/nature16940

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John S. de Banzie

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