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User:John S. de Banzie/Sandbox 4
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Focusing <scene name='72/726441/Rnascene/1'>on the RNAs</scene> reveals secondary structure and extensive base pairing between the U4 and U6 snRNAs. | Focusing <scene name='72/726441/Rnascene/1'>on the RNAs</scene> reveals secondary structure and extensive base pairing between the U4 and U6 snRNAs. | ||
| - | The U2 snRNP <scene name='72/726441/Dockscene/1'> | + | The spliceosome is assembled from the U4/U6.U5 tri-snRNP, the U1 snRNP, and the U2 snRNP. The U2 snRNP interacts with the region highlighted in blue <scene name='72/726441/Dockscene/1'>in this view</scene>. The U1 snRNP interacts with the U2 snRNP. The initial assembly is inactive; extensive conformational changes (including unwinding of the U4/U6 base pairing) are required for activation of the spliceosome. |
For the source article see Nguyen et al, 2016<ref>DOI 10.1038/nature16940</ref>. | For the source article see Nguyen et al, 2016<ref>DOI 10.1038/nature16940</ref>. | ||
Current revision
Yeast U4/U6.U5 tri-snRNP
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References
- ↑ Nguyen TH, Galej WP, Bai XC, Oubridge C, Newman AJ, Scheres SH, Nagai K. Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 A resolution. Nature. 2016 Feb 18;530(7590):298-302. doi: 10.1038/nature16940. Epub 2016 Feb 1. PMID:26829225 doi:http://dx.doi.org/10.1038/nature16940
