Gyrase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 2: Line 2:
==Function==
==Function==
-
'''Gyrase (Gyr)''' is a type of topoisomerase II in prokaryotes which unwinds double stranded DNA. The DNA Gyr cutting allows the formation of a negative DNA supercoil which enables replication of DNA. Gyr consists of 2 subunits: GyrA and GyrB. Reverse gyrase (Top-RG) is a type of topoisomerase I which catalyses the formation of positive DNA supercoil. <ref>PMID:16397501</ref> See also [[Isomerases]].
+
'''Gyrase (Gyr)''' is a type of topoisomerase II in prokaryotes which unwinds double stranded DNA. The DNA Gyr cutting allows the formation of a negative DNA supercoil which enables replication of DNA<StructureSection load='2pm4' size='350' side='right' caption='Human α-defensin 1 (PDB entry [[2pm4]])' scene='50/509378/Cv/4'>. Gyr consists of 2 subunits: GyrA and GyrB. '''Reverse gyrase''' (Top-RG) is a type of topoisomerase I which catalyses the formation of positive DNA supercoil. <ref>PMID:15673717</ref> See also [[Isomerases]].
==Relevance==
==Relevance==

Revision as of 07:46, 20 March 2016

Gyrase subunit A N-terminal (yellow) and subunit B C-terminal (green) complex with DNA (magenta, cyan), inhibitor, sulfate and Mn+2 ion (purple) (PDB entry 4plb)

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, David Canner, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Gyrase"
Personal tools