Glycosylasparaginase

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== Structural highlights ==
== Structural highlights ==
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Mammalian AGA substrate is the protein-sugar bond of Asn-GlcNac<ref>PMID:17157318</ref>.
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<scene name='59/591999/Cv/2'>Glycosylated human glycosylasparaginase α and β subunits with asparagine</scene>. Mammalian AGA substrate is the protein-sugar bond of Asn-GlcNac<ref>PMID:17157318</ref>.
</StructureSection>
</StructureSection>

Revision as of 09:54, 20 March 2016

Structure of glycosylated human glycosylasparaginase α (magenta and cyan) and β (green and yellow) subunits complex with asparagine (PDB code 2gl9).

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3D structures of glycosylasparaginase

Updated on 20-March-2016

References

  1. ↑ Qian X, Guan C, Guo HC. A dual role for an aspartic acid in glycosylasparaginase autoproteolysis. Structure. 2003 Aug;11(8):997-1003. PMID:12906830
  2. ↑ Ikonen E, Peltonen L. Mutations causing aspartylglucosaminuria (AGU): a lysosomal accumulation disease. Hum Mutat. 1992;1(5):361-5. PMID:1301945 doi:http://dx.doi.org/10.1002/humu.1380010503
  3. ↑ Wang Y, Guo HC. Crystallographic snapshot of a productive glycosylasparaginase-substrate complex. J Mol Biol. 2007 Feb 9;366(1):82-92. Epub 2006 Sep 26. PMID:17157318 doi:10.1016/j.jmb.2006.09.051

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Michal Harel, Alexander Berchansky

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