Heat shock factor
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
<StructureSection load='3hts' size='400' side='right' caption='Structure of monomer of the dimeric heat shock protein complex with DNA and glycerol (PDB entry [[3hts]])' scene=''> | <StructureSection load='3hts' size='400' side='right' caption='Structure of monomer of the dimeric heat shock protein complex with DNA and glycerol (PDB entry [[3hts]])' scene=''> | ||
| - | + | == Function == | |
| - | '''Heat shock factor''' (HSF) are transcriptional activators of heat shock genes. HSF bind to heat shock sequence elements throughout the genome with a | + | '''Heat shock factor''' (HSF) are transcriptional activators of heat shock genes. HSF bind to heat shock sequence elements throughout the genome with a consensus array of three oppositely oriented sequence AGGAN and activate transcription. Each HSF monomer contains one C-terminal and 3 N-terminal leucine zippers. Two sequences flanking the N-terminal leucine zippers contain the consensus nuclear localization signal (NLS). The DNA-binding domain (DBD) of HSF lies in the N-terminal of the first NLS region<ref>PMID:8441385</ref>. |
| + | |||
| + | == Structural highlights == | ||
| + | The DBD region of HSF shows multiple protein-DNA interactions as well as water-mediated interactions <ref>PMID:10331875</ref>. | ||
==3D structures of heat shock factor== | ==3D structures of heat shock factor== | ||
| Line 14: | Line 17: | ||
[[3hts]] – KlHSF DBD + DNA<br /> | [[3hts]] – KlHSF DBD + DNA<br /> | ||
[[1fyk]], [[1fyl]], [[1fym]] – KlHSF DBD (mutant) + DNA | [[1fyk]], [[1fyl]], [[1fym]] – KlHSF DBD (mutant) + DNA | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:52, 20 March 2016
| |||||||||||
