Hemagglutinin-esterase
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_3i1l| PDB=3i1l | SIZE=400| SCENE= |right|CAPTION=Pig glycosylated hemagglutinin-esterase glycoprotein complex with receptor and acetate [[3i1l]]}} | {{STRUCTURE_3i1l| PDB=3i1l | SIZE=400| SCENE= |right|CAPTION=Pig glycosylated hemagglutinin-esterase glycoprotein complex with receptor and acetate [[3i1l]]}} | ||
| - | + | == Function == | |
| - | + | '''Hemagglutinin-esterase''' (HE) is a glycoprotein of the envelopes of some viruses. HE recognizes the host cell surface receptor - a sialic acid derivative. The esterase region of the HE is responsible for the destruction of the receptor<ref>PMID:16575523</ref>. The HE is a trimer and each monomer contains 3 domains: the membrane fusion domain, the esterase domain and the receptor-binding domain. | |
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| - | '''Hemagglutinin-esterase''' (HE) is a glycoprotein of the envelopes of some viruses. HE recognizes the host cell surface receptor. The esterase region of the HE is responsible for the destruction of the receptor. The HE is a trimer and each monomer contains 3 domains: the membrane fusion domain, the esterase domain and the receptor-binding domain. | + | |
==3D structures of hemagglutinin-esterase== | ==3D structures of hemagglutinin-esterase== | ||
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[[3cl4]] – bHE – bovine<br /> | [[3cl4]] – bHE – bovine<br /> | ||
| - | [[3cl5]] – bHE (mutant) + | + | [[3cl5]] – bHE (mutant) + receptor<br /> |
[[3i1k]] – PtHE (mutant) – porcine torovirus<br /> | [[3i1k]] – PtHE (mutant) – porcine torovirus<br /> | ||
[[3i1l]] – PtHE (mutant) + receptor<br /> | [[3i1l]] – PtHE (mutant) + receptor<br /> | ||
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[[3i27]] – BtHE + receptor<br /> | [[3i27]] – BtHE + receptor<br /> | ||
[[4c7l]] – mhvHE (mutant) – murine hepatitis virus<br /> | [[4c7l]] – mhvHE (mutant) – murine hepatitis virus<br /> | ||
| - | [[4c7w]] – mhvHE (mutant) + | + | [[4c7w]] – mhvHE (mutant) + receptor<br /> |
| - | + | == References == | |
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 12:02, 20 March 2016
Function
Hemagglutinin-esterase (HE) is a glycoprotein of the envelopes of some viruses. HE recognizes the host cell surface receptor - a sialic acid derivative. The esterase region of the HE is responsible for the destruction of the receptor[1]. The HE is a trimer and each monomer contains 3 domains: the membrane fusion domain, the esterase domain and the receptor-binding domain.
3D structures of hemagglutinin-esterase
Updated on 20-March-2016
3cl4 – bHE – bovine
3cl5 – bHE (mutant) + receptor
3i1k – PtHE (mutant) – porcine torovirus
3i1l – PtHE (mutant) + receptor
3i26 – BtHE – bovine torovirus
3i27 – BtHE + receptor
4c7l – mhvHE (mutant) – murine hepatitis virus
4c7w – mhvHE (mutant) + receptor
References
- ↑ de Groot RJ. Structure, function and evolution of the hemagglutinin-esterase proteins of corona- and toroviruses. Glycoconj J. 2006 Feb;23(1-2):59-72. PMID:16575523 doi:http://dx.doi.org/10.1007/s10719-006-5438-8
