Hepatocyte growth factor activator
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
<StructureSection load='2r0k' size='340' side='right' caption='Human hepatocyte growth factor activator (grey) complex with antibody light (red) and heavy (aqua) chains (PDB code [[2r0k]])' scene=''> | <StructureSection load='2r0k' size='340' side='right' caption='Human hepatocyte growth factor activator (grey) complex with antibody light (red) and heavy (aqua) chains (PDB code [[2r0k]])' scene=''> | ||
| - | '''Hepatocyte growth factor activator''' (HGFA) is a serine protease which links tissue injury to activation of hepatocyte growth factor (HGF). HGFA converts HGF from its latent single-chain form to a heterodimeric active form. HGFA is synthesized as an inactive precursor which is converted to a heterodimer via proteolysis as a result of tissue injury. | ||
| - | |||
== Function == | == Function == | ||
| + | '''Hepatocyte growth factor activator''' (HGFA) is a serine protease which links tissue injury to activation of hepatocyte growth factor (HGF). HGFA converts HGF from its latent single-chain form to a heterodimeric active form. HGFA is synthesized as an inactive precursor which is converted to a heterodimer via proteolysis as a result of tissue injury<ref>PMID:20402766</ref>. | ||
== Disease == | == Disease == | ||
== Relevance == | == Relevance == | ||
| + | Lower activity of HGFA results in impaired regeneration of damaged mucosal epithelium and may contribute to the progression of fibrotic lung cancer<ref>PMID:20142763</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 10:16, 21 March 2016
| |||||||||||
3D Structures of hepatocyte growth factor activator
Updated on 21-March-2016
1ybw – hHGFA protease domain – human
1yc0 – hHGFA protease domain + Kunitz-type protease inhibitor
2r0l, 2r0k, 2wub, 2wuc, 3k2u – hHGFA protease domain + antibody
References
- ↑ Miyazawa K. Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor. FEBS J. 2010 May;277(10):2208-14. doi: 10.1111/j.1742-4658.2010.07637.x. Epub, 2010 Apr 2. PMID:20402766 doi:http://dx.doi.org/10.1111/j.1742-4658.2010.07637.x
- ↑ Wu KL, Li YQ, Tabassum A, Lu WY, Aubert I, Wong CS. Loss of neuronal protein expression in mouse hippocampus after irradiation. J Neuropathol Exp Neurol. 2010 Mar;69(3):272-80. doi:, 10.1097/NEN.0b013e3181d1afe4. PMID:20142763 doi:http://dx.doi.org/10.1097/NEN.0b013e3181d1afe4
