DNA methyltransferase
From Proteopedia
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*'''Methylcytosine DNMT''' methylates the 5 position of cytosine. <ref>PMID:8127644</ref><br /> | *'''Methylcytosine DNMT''' methylates the 5 position of cytosine. <ref>PMID:8127644</ref><br /> | ||
*'''Methyladenine DNMT''' methylates the 6 position of adenine. <ref>PMID:12732637</ref><br /> | *'''Methyladenine DNMT''' methylates the 6 position of adenine. <ref>PMID:12732637</ref><br /> | ||
| + | *'''HhaI DNA methyltransferase''' (HDMT), a DNMT from ''Haemophilus haemolyticus'' recognizes the 5’-GCGC-3’ DNA sequence and methylates the first cytosine to convert it to 5-methylcytosine. The SAM serves as the methyl donor in the reaction and is converted to to S-adenosyl-L-homocysteine (SAH) by the reaction<ref>PMID:12139442</ref>. | ||
== Relevance == | == Relevance == | ||
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**[[2adm]] - Ta-adenine DNMT Taqi + SAM<br /> | **[[2adm]] - Ta-adenine DNMT Taqi + SAM<br /> | ||
**[[1g60]] - adenine DNMT + SAM – ''Moraxella bovis'' | **[[1g60]] - adenine DNMT + SAM – ''Moraxella bovis'' | ||
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| + | *HhaI DNA methyltransferase | ||
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| + | **[[1fjx]], [[2hmy]] – HhHDMT + SAM – ''Haemophilus haemolyticus'' <BR /> | ||
| + | **[[1svu]] – HhHDMT (mutant) + SAH <BR /> | ||
| + | **[[1hmy]], [[1mht]], [[3mht]], [[4mht]], [[5mht]], [[7mht]], [[8mht]], [[2hr1]], [[3eeo]] – HhHDMT + DNA + SAH <BR /> | ||
| + | **[[2i9k]], [[2z6a]], [[2z6u]], [[2zcj]] – HhHDMT (mutant) + DNA + SAH <BR /> | ||
| + | **[[6mht]] – HhHDMT + DNA + SAH + thiodeoxycytidine <BR /> | ||
| + | **[[9mht]] – HhHDMT + DNA + SAH + abasic dideoxyribose <BR /> | ||
| + | **[[1skm]] – HhHDMT + DNA + SAH + bicyclohexane <BR /> | ||
| + | **[[10mh]] – HhHDMT + DNA + SAH + dihydroazacytosine <BR /> | ||
| + | **[[1m0e]] – HhHDMT + DNA + SAH + zebularine <BR /> | ||
| + | **[[2c7o]], [[2c7p]], [[2c7q]] – HhHDMT + DNA + SAH + methyl cytosine + aminopurine <BR /> | ||
| + | **[[2c7r]] – HhHDMT (mutant) + DNA + SAH + methyl cytosine + aminopurine <BR /> | ||
| + | **[[2z6q]] – HhHDMT (mutant) + DNA + SAH + deoxycytidine <BR /> | ||
| + | **[[2uyc]], [[2uyh]], [[2uz4]] – HhHDMT (mutant) + DNA + SAH + methyl cytosine <BR /> | ||
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}} | }} | ||
Revision as of 11:29, 21 March 2016
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3D Structures of DNA methyltransferase
Updated on 21-March-2016
References
- ↑ Kaina B, Christmann M, Naumann S, Roos WP. MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents. DNA Repair (Amst). 2007 Aug 1;6(8):1079-99. Epub 2007 May 7. PMID:17485253 doi:http://dx.doi.org/10.1016/j.dnarep.2007.03.008
- ↑ Kumar S, Cheng X, Klimasauskas S, Mi S, Posfai J, Roberts RJ, Wilson GG. The DNA (cytosine-5) methyltransferases. Nucleic Acids Res. 1994 Jan 11;22(1):1-10. PMID:8127644
- ↑ Thomas CB, Scavetta RD, Gumport RI, Churchill ME. Structures of liganded and unliganded RsrI N6-adenine DNA methyltransferase: a distinct orientation for active cofactor binding. J Biol Chem. 2003 Jul 11;278(28):26094-101. Epub 2003 May 4. PMID:12732637 doi:http://dx.doi.org/10.1074/jbc.M303751200
- ↑ Sankpal UT, Rao DN. Structure, function, and mechanism of HhaI DNA methyltransferases. Crit Rev Biochem Mol Biol. 2002;37(3):167-97. PMID:12139442 doi:http://dx.doi.org/10.1080/10409230290771492
