Hirudin
From Proteopedia
(Difference between revisions)
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| - | {{STRUCTURE_1hic| PDB=1hic | SIZE=400| SCENE= |right|CAPTION=Hirudin, [[1hic]] }} | ||
| - | [[Hirudin]] (Hir) is a powerful anticoagulant which is found in the leech salivary glands. It is an inhibitor of thrombin (Thr) which converts [[Fibrinogen|fibrinogen]] to [[Fibrin|fibrin]] upon blood clotting. Thrombin is produced upon enzymatic cleavage of prothrombin (ProThr). '''Hirugen''' (Hirg) is a dodecapeptide of the C-terminal of Hir (sequence NDGDFEEIPEEYL | + | <StructureSection load='3htc' size='350' side='right' caption='Human α-defensin 1 (PDB entry [[2pm4]])' scene=''> |
| + | == Function == | ||
| + | [[Hirudin]] (Hir) is a powerful anticoagulant which is found in the leech salivary glands. It is an inhibitor of thrombin (Thr) which converts [[Fibrinogen|fibrinogen]] to [[Fibrin|fibrin]] upon blood clotting<ref>PMID:9579630</ref>. Thrombin is produced upon enzymatic cleavage of prothrombin (ProThr). '''Hirugen''' (Hirg) is a dodecapeptide of the C-terminal of Hir (sequence NDGDFEEIPEEYL). For additional details see [[Sean Swale/Human Thrombin Inhibitor]]. | ||
== 3D Structures of Hirudin == | == 3D Structures of Hirudin == | ||
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**[[1zrb]], [[1z71]], [[1sl3]], [[1ta2]], [[1ta6]], [[1zgi]], [[1zgv]], [[2uuk]], [[2uuj]], [[2jh0]], [[2jh5]], [[2jh6]], [[2c8w]], [[2c8x]], [[2c8y]], [[2c8z]], [[2c90]], [[2c93]], [[8kme]] – Hirg+α-hThr+inhibitor<br /> | **[[1zrb]], [[1z71]], [[1sl3]], [[1ta2]], [[1ta6]], [[1zgi]], [[1zgv]], [[2uuk]], [[2uuj]], [[2jh0]], [[2jh5]], [[2jh6]], [[2c8w]], [[2c8x]], [[2c8y]], [[2c8z]], [[2c90]], [[2c93]], [[8kme]] – Hirg+α-hThr+inhibitor<br /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 07:54, 22 March 2016
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