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Hirudin
From Proteopedia
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| - | <StructureSection load='3htc' size='350' side='right' caption=' | + | <StructureSection load='3htc' size='350' side='right' caption='Hirudin (wheat) complex with thrombin small subunit (aqua) and large subunit (red) (PDB entry [[3htc]])' scene=''> |
== Function == | == Function == | ||
[[Hirudin]] (Hir) is a powerful anticoagulant which is found in the leech salivary glands. It is an inhibitor of thrombin (Thr) which converts [[Fibrinogen|fibrinogen]] to [[Fibrin|fibrin]] upon blood clotting<ref>PMID:9579630</ref>. Thrombin is produced upon enzymatic cleavage of prothrombin (ProThr). '''Hirugen''' (Hirg) is a dodecapeptide of the C-terminal of Hir (sequence NDGDFEEIPEEYL). For additional details see [[Sean Swale/Human Thrombin Inhibitor]]. | [[Hirudin]] (Hir) is a powerful anticoagulant which is found in the leech salivary glands. It is an inhibitor of thrombin (Thr) which converts [[Fibrinogen|fibrinogen]] to [[Fibrin|fibrin]] upon blood clotting<ref>PMID:9579630</ref>. Thrombin is produced upon enzymatic cleavage of prothrombin (ProThr). '''Hirugen''' (Hirg) is a dodecapeptide of the C-terminal of Hir (sequence NDGDFEEIPEEYL). For additional details see [[Sean Swale/Human Thrombin Inhibitor]]. | ||
Revision as of 07:57, 22 March 2016
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3D Structures of Hirudin
Updated on 22-March-2016
References
- ↑ Fenton JW 2nd, Ofosu FA, Brezniak DV, Hassouna HI. Thrombin and antithrombotics. Semin Thromb Hemost. 1998;24(2):87-91. PMID:9579630 doi:http://dx.doi.org/10.1055/s-2007-995828
