Hirudin

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**[[1hrt]], [[3htc]], [[4htc]] - Hir +hThr L&H chains<br />
**[[1hrt]], [[3htc]], [[4htc]] - Hir +hThr L&H chains<br />
-
**[[3da9]], [[3utu]] - Hir peptide+hThr L&H chains<br />
 
-
**[[3qtv]], [[3qwc]], [[3qx5]] - Hir peptide + hThr L&H chains + pyridine derivative<br />
 
-
**[[3rlw]], [[3rly]], [[3rm0]], [[3rm2]], [[3rml]], [[3rmm]], [[3rmn]], [[3rmo]] - Hir peptide + hThr L&H chains + inhibitor<br />
 
**[[3qto]] - Hir +hThr L&H chains + pyridine derivative
**[[3qto]] - Hir +hThr L&H chains + pyridine derivative
* Hirugen + Thrombin light and heavy chains
* Hirugen + Thrombin light and heavy chains
-
**[[2zhe]], [[2zhf]], [[2zhw]], [[2zg0]], [[2zfq]], [[2zfr]], [[1c5l]], [[1hxf]], [[1hah]], [[1hai]], [[1abi]], [[1abj]], [[1hgt]], [[2uuf]], [[1aix]], [[1ay6]], [[1awf]], [[2hgt]] - Hirg+ hThr L&H chains<br />
+
**[[2zhe]], [[2zhf]], [[2zhw]], [[2zg0]], [[2zfq]], [[2zfr]], [[1c5l]], [[1hxf]], [[1hah]], [[1hai]], [[1abi]], [[1abj]], [[1hgt]], [[2uuf]], [[1aix]], [[1ay6]], [[1awf]], [[2hgt]], [[3da9]], [[3utu]] - Hirg+ hThr L&H chains<br />
* Hirugen + prothrombin
* Hirugen + prothrombin
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**[[1fph]], [[7kme]], [[1d6w]] - Hirg +hThr L&H chains+polypeptide<br />
**[[1fph]], [[7kme]], [[1d6w]] - Hirg +hThr L&H chains+polypeptide<br />
**[[1hxe]] - Hirg +hThr L&H chains+Rb<br />
**[[1hxe]] - Hirg +hThr L&H chains+Rb<br />
-
**[[1ypk]], [[1riw]], [[1mu6]], [[1mu8]], [[1mue]], [[1no9]], [[1oyt]], [[1o2g]], [[1ny2]], [[1gj4]], [[1gj5]], [[1kts]], [[1ktt]], [[1ghv]], [[1ghw]], [[1ghx]], [[1ghy]], [[1h8i]], [[1h8d]], [[1c5n]], [[1c5o]], [[1c1u]], [[1c1v]], [[1c1w]], [[1qj1]], [[1qj6]], [[1qj7]], [[1qbv]], [[1bcu]], [[1a2c]], [[1a61]], [[1a46]], [[1a5g]], [[1b5g]], [[1ad8]], [[1ai8]], [[1tom]], [[1bmm]], [[1bmn]], [[1lhc]], [[1lhd]], [[1lhe]], [[1lhf]], [[1lhg]], [[1uma]], [[1aht]], [[1fpc]], [[3hat]], [[1tmu]], [[1dwb]], [[1dwc]], [[1dwd]], [[1dwe]], [[1tmb]], [[3f68]], [[3eq0]], [[3dt0]], [[3dux]], [[3dhk]], [[2znk]], [[2zo3]], [[3d49]], [[2zhq]], [[2zi2]], [[2ziq]], [[2zff]], [[2zfp]], [[2zgb]], [[2zgx]], [[2zf0]], [[2zc9]], [[2zda]], [[2zdv]], [[3egk]], [[2pw8]], [[3c27]], [[2r2m]], [[2cf8]], [[2cf9]], [[2bdy]], [[2v3h]], [[2v3o]], [[1w7g]], [[1ype]], [[1ypg]], [[1ypj]], [[3biu]], [[3biv]], [[1doj]], [[1ypl]], [[1ypm]], [[1vzq]], [[1way]], [[1wbg]], [[1k21]], [[1k22]], [[1afe]], [[1ae8]] ,[[1a3b]], [[1a3e]], [[1vr1]], [[2bvr]], [[2bvs]], [[2bvx]], [[2bxt]], [[2bxu]], [[2gde]], [[2pks]], [[3ldx]], [[3p17]], [[1d9i]], [[1xm1]], [[4n3l]], [[4nze]], [[1ba8]], [[1bb0]], [[1c4u]], [[1ca8]], [[1d3d]], [[1d3p]], [[1d3q]], [[1d3t]], [[1d4p]], [[1hdt]], [[1ihs]], [[1iht]], [[1o0d]], [[1qhr]], [[1tbz]], [[4ayv]], [[4ayy]], [[4az2]] – Hirg+ hThr L&H chains+inhibitor<br />
+
**[[1ypk]], [[1riw]], [[1mu6]], [[1mu8]], [[1mue]], [[1no9]], [[1oyt]], [[1o2g]], [[1ny2]], [[1gj4]], [[1gj5]], [[1kts]], [[1ktt]], [[1ghv]], [[1ghw]], [[1ghx]], [[1ghy]], [[1h8i]], [[1h8d]], [[1c5n]], [[1c5o]], [[1c1u]], [[1c1v]], [[1c1w]], [[1qj1]], [[1qj6]], [[1qj7]], [[1qbv]], [[1bcu]], [[1a2c]], [[1a61]], [[1a46]], [[1a5g]], [[1b5g]], [[1ad8]], [[1ai8]], [[1tom]], [[1bmm]], [[1bmn]], [[1lhc]], [[1lhd]], [[1lhe]], [[1lhf]], [[1lhg]], [[1uma]], [[1aht]], [[1fpc]], [[3hat]], [[1tmu]], [[1dwb]], [[1dwc]], [[1dwd]], [[1dwe]], [[1tmb]], [[3f68]], [[3eq0]], [[3dt0]], [[3dux]], [[3dhk]], [[2znk]], [[2zo3]], [[3d49]], [[2zhq]], [[2zi2]], [[2ziq]], [[2zff]], [[2zfp]], [[2zgb]], [[2zgx]], [[2zf0]], [[2zc9]], [[2zda]], [[2zdv]], [[3egk]], [[2pw8]], [[3c27]], [[2r2m]], [[2cf8]], [[2cf9]], [[2bdy]], [[2v3h]], [[2v3o]], [[1w7g]], [[1ype]], [[1ypg]], [[1ypj]], [[3biu]], [[3biv]], [[1doj]], [[1ypl]], [[1ypm]], [[1vzq]], [[1way]], [[1wbg]], [[1k21]], [[1k22]], [[1afe]], [[1ae8]] ,[[1a3b]], [[1a3e]], [[1vr1]], [[2bvr]], [[2bvs]], [[2bvx]], [[2bxt]], [[2bxu]], [[2gde]], [[2pks]], [[3ldx]], [[3p17]], [[1d9i]], [[1xm1]], [[4n3l]], [[4nze]], [[1ba8]], [[1bb0]], [[1c4u]], [[1ca8]], [[1d3d]], [[1d3p]], [[1d3q]], [[1d3t]], [[1d4p]], [[1hdt]], [[1ihs]], [[1iht]], [[1o0d]], [[1qhr]], [[1tbz]], [[4ayv]], [[4ayy]], [[4az2]], [[3rlw]], [[3rly]], [[3rm0]], [[3rm2]], [[3rml]], [[3rmm]], [[3rmn]], [[3rmo]], [[3qtv]], [[3qwc]], [[3qx5]] – Hirg+ hThr L&H chains+inhibitor<br />
**[[2feq]], [[2fes]] – Hirg analog + hThr L&H chains+inhibitor<br />
**[[2feq]], [[2fes]] – Hirg analog + hThr L&H chains+inhibitor<br />
**[[3sha]], [[3shc]], [[3si3]], [[3si4]], [[3sv2]], [[3t5f]], [[3u98]], [[3u9a]], [[3uwj]], [[4ban]], [[4bao]], [[4e7r]], [[4loy]] – Hirg variant 2 + hThr L&H chains+inhibitor<br />
**[[3sha]], [[3shc]], [[3si3]], [[3si4]], [[3sv2]], [[3t5f]], [[3u98]], [[3u9a]], [[3uwj]], [[4ban]], [[4bao]], [[4e7r]], [[4loy]] – Hirg variant 2 + hThr L&H chains+inhibitor<br />

Revision as of 10:01, 22 March 2016

Hirudin (wheat) complex with glycosylated thrombin small subunit (aqua) and large subunit (red) (PDB entry 4htc)

Drag the structure with the mouse to rotate

3D Structures of Hirudin

Updated on 22-March-2016

References

  1. ↑ Fenton JW 2nd, Ofosu FA, Brezniak DV, Hassouna HI. Thrombin and antithrombotics. Semin Thromb Hemost. 1998;24(2):87-91. PMID:9579630 doi:http://dx.doi.org/10.1055/s-2007-995828
  2. ↑ Stamenova PK, Marchetti T, Simeonov I. Efficacy and safety of topical hirudin (Hirudex): a double-blind, placebo-controlled study. Eur Rev Med Pharmacol Sci. 2001 Mar-Apr;5(2):37-42. PMID:11863317
  3. ↑ Johnson PH. Hirudin: clinical potential of a thrombin inhibitor. Annu Rev Med. 1994;45:165-77. PMID:8198374 doi:http://dx.doi.org/10.1146/annurev.med.45.1.165
  4. ↑ Rydel TJ, Tulinsky A, Bode W, Huber R. Refined structure of the hirudin-thrombin complex. J Mol Biol. 1991 Sep 20;221(2):583-601. PMID:1920434

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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