1gz0
From Proteopedia
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|PDB= 1gz0 |SIZE=350|CAPTION= <scene name='initialview01'>1gz0</scene>, resolution 2.50Å | |PDB= 1gz0 |SIZE=350|CAPTION= <scene name='initialview01'>1gz0</scene>, resolution 2.50Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gz0 OCA], [http://www.ebi.ac.uk/pdbsum/1gz0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gz0 RCSB]</span> | ||
}} | }} | ||
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[[Category: structural genomic]] | [[Category: structural genomic]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:54:19 2008'' |
Revision as of 17:54, 30 March 2008
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| , resolution 2.50Å | |||||||
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
23S RIBOSOMAL RNA G2251 2'O-METHYLTRANSFERASE RLMB
Overview
In Escherichia coli, RlmB catalyzes the methylation of guanosine 2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. The crystal structure of this 2'O-methyltransferase has been determined at 2.5 A resolution. RlmB consists of an N-terminal domain connected by a flexible extended linker to a catalytic C-terminal domain and forms a dimer in solution. The C-terminal domain displays a divergent methyltransferase fold with a unique knotted region, and lacks the classic AdoMet binding site features. The N-terminal domain is similar to ribosomal proteins L7 and L30, suggesting a role in 23S rRNA recognition. The conserved residues in this novel family of 2'O-methyltransferases cluster in the knotted region, suggesting the location of the catalytic and AdoMet binding sites.
About this Structure
1GZ0 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot., Michel G, Sauve V, Larocque R, Li Y, Matte A, Cygler M, Structure. 2002 Oct;10(10):1303-15. PMID:12377117
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