User:Daniel Schemenauer/Sandbox 1
From Proteopedia
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== Introduction == | == Introduction == | ||
=== Biological Background === | === Biological Background === | ||
| - | G-Coupled Protein Receptors (GPCRs) are divided into four major classes; Class A,B,C, and F.<ref name="MSGPCR">PMID:23407534</ref>. Metabotropic Glutamate Receptor 5 (mGlu<sub>5</sub>) is a class C GPCR that is involved in the G<sub>q</sub> pathway <ref name="CCGPCR">PMID:12782243</ref>. | + | G-Coupled Protein Receptors (GPCRs) are divided into four major classes; Class A,B,C, and F.<ref name="MSGPCR">PMID:23407534</ref>. Metabotropic Glutamate Receptor 5 (mGlu<sub>5</sub>) is a class C GPCR that is involved in the G<sub>q</sub> pathway <ref name="CCGPCR">PMID:12782243</ref>. mGlu5<sub>5</sub>is highly expressed in neuronal and glial cells. |
=== Importance === | === Importance === | ||
Revision as of 13:44, 22 March 2016
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References
- ↑ Venkatakrishnan AJ, Deupi X, Lebon G, Tate CG, Schertler GF, Babu MM. Molecular signatures of G-protein-coupled receptors. Nature. 2013 Feb 14;494(7436):185-94. doi: 10.1038/nature11896. PMID:23407534 doi:http://dx.doi.org/10.1038/nature11896
- ↑ Pin JP, Galvez T, Prezeau L. Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors. Pharmacol Ther. 2003 Jun;98(3):325-54. PMID:12782243
