1gzt
From Proteopedia
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|PDB= 1gzt |SIZE=350|CAPTION= <scene name='initialview01'>1gzt</scene>, resolution 1.30Å | |PDB= 1gzt |SIZE=350|CAPTION= <scene name='initialview01'>1gzt</scene>, resolution 1.30Å | ||
|SITE= <scene name='pdbsite=FUA:Ca+Binding+Site+For+Chain+D'>FUA</scene> | |SITE= <scene name='pdbsite=FUA:Ca+Binding+Site+For+Chain+D'>FUA</scene> | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gzt OCA], [http://www.ebi.ac.uk/pdbsum/1gzt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gzt RCSB]</span> | ||
}} | }} | ||
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[[Category: Imberty, A.]] | [[Category: Imberty, A.]] | ||
[[Category: Mitchell, E.]] | [[Category: Mitchell, E.]] | ||
| - | [[Category: CA]] | ||
| - | [[Category: FUC]] | ||
[[Category: fucose]] | [[Category: fucose]] | ||
[[Category: lectin]] | [[Category: lectin]] | ||
[[Category: sugar-binding protein]] | [[Category: sugar-binding protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:54:45 2008'' |
Revision as of 17:54, 30 March 2008
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| , resolution 1.30Å | |||||||
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| Sites: | |||||||
| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
PSEUDOMONAS AERUGINOSA LECTIN II (PA-IIL) TOGETHER WITH FUCOSE
Overview
Pseudomonas aeruginosa galactose- and fucose-binding lectins (PA-IL and PA-IIL) contribute to the virulence of this pathogenic bacterium, which is a major cause of morbidity and mortality in cystic fibrosis patients. The crystal structure of PA-IIL in complex with fucose reveals a tetrameric structure. Each monomer displays a nine-stranded, antiparallel b-sandwich arrangement and contains two close calcium cations that mediate the binding of fucose in a recognition mode unique among carbohydrate-protein interactions. Experimental binding studies, together with theoretical docking of fucose-containing oligosaccharides, are consistent with the assumption that antigens of the Lewis a (Le(a)) series may be the preferred ligands of this lectin. Precise knowledge of the lectin-binding site should allow a better design of new antibacterial-adhesion prophylactics.
About this Structure
1GZT is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.
Reference
Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients., Mitchell E, Houles C, Sudakevitz D, Wimmerova M, Gautier C, Perez S, Wu AM, Gilboa-Garber N, Imberty A, Nat Struct Biol. 2002 Dec;9(12):918-21. PMID:12415289
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