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Histone deacetylase

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{{STRUCTURE_3ewf| PDB=3ewf | SIZE=400| SCENE= |right|CAPTION=Human HDAC8 tetramer complex with polypeptide, amino-methylcoumarine, K+ (purple) and Zn+2 (grey) ions, [[3ewf]] }}
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<StructureSection load='3glr' size='350' side='right' caption='Human α-defensin 1 (PDB entry [[2pm4]])' scene=''>
== Function ==
== Function ==
'''Histone deacetylase''' (HDAC) catalyzes the removal of acetyl group from ε-N-acetyl lysine in histones<ref>PMID:23752268</ref>. HDAC contains Zn. DNA expression is regulated by acetylation and de-acetylation. SAHA is a common inhibitor of HDAC. HDAC are classified according to their domain organization into 4 classes. <br />
'''Histone deacetylase''' (HDAC) catalyzes the removal of acetyl group from ε-N-acetyl lysine in histones<ref>PMID:23752268</ref>. HDAC contains Zn. DNA expression is regulated by acetylation and de-acetylation. SAHA is a common inhibitor of HDAC. HDAC are classified according to their domain organization into 4 classes. <br />

Revision as of 12:03, 23 March 2016

Human α-defensin 1 (PDB entry 2pm4)

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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