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Histone deacetylase
From Proteopedia
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| - | + | <StructureSection load='3glr' size='350' side='right' caption='Human sirtuin-3 (grey) complex with peptide containing acetylated lysine, sulfate, carbonate, glycerol and Zn+2 ion (PDB entry [[3glr]])' scene=''> | |
| - | <StructureSection load='3glr' size='350' side='right' caption='Human | + | |
== Function == | == Function == | ||
'''Histone deacetylase''' (HDAC) catalyzes the removal of acetyl group from ε-N-acetyl lysine in histones<ref>PMID:23752268</ref>. HDAC contains Zn. DNA expression is regulated by acetylation and de-acetylation. SAHA is a common inhibitor of HDAC. HDAC are classified according to their domain organization into 4 classes. <br /> | '''Histone deacetylase''' (HDAC) catalyzes the removal of acetyl group from ε-N-acetyl lysine in histones<ref>PMID:23752268</ref>. HDAC contains Zn. DNA expression is regulated by acetylation and de-acetylation. SAHA is a common inhibitor of HDAC. HDAC are classified according to their domain organization into 4 classes. <br /> | ||
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== Relevance == | == Relevance == | ||
HDAC inhibitors are used in cancer therapy<ref>PMID:11902574</ref>. Sirtuins play a role in cancer, metabolic activity and neurodegenerative diseases<ref>PMID:17456799</ref>. HDAC inhibitor SAHA or Vorinostat is used in the treatment of cutaneous T cell lymphoma<ref>PMID:17962618</ref>. | HDAC inhibitors are used in cancer therapy<ref>PMID:11902574</ref>. Sirtuins play a role in cancer, metabolic activity and neurodegenerative diseases<ref>PMID:17456799</ref>. HDAC inhibitor SAHA or Vorinostat is used in the treatment of cutaneous T cell lymphoma<ref>PMID:17962618</ref>. | ||
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| + | == Structural highlights == | ||
| + | The acetylated lysine of the peptide is inserted in an extended conformation between the 2 domains of SIRT3 - a large Rossman fold, NAD-binding domain and a small Zn-binding one)<ref>PMID:19535340</ref>.<br />. | ||
== 3D Structures of histone deacetylase == | == 3D Structures of histone deacetylase == | ||
Revision as of 07:55, 24 March 2016
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