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Histone methyltransferase
From Proteopedia
(Difference between revisions)
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== Relevance == | == Relevance == | ||
| - | Inhibitors of the histone-lysine N-methyltransferase SMYD2 which represses the tumor-suppressing activities of p53 are studied as cancer therapy | + | Inhibitors of the histone-lysine N-methyltransferase SMYD2 which represses the tumor-suppressing activities of p53 are studied as cancer therapy drugs<ref>PMID:21782458</ref>. |
== Disease == | == Disease == | ||
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*Histone-lysine N-methyltransferase binary complexes | *Histone-lysine N-methyltransferase binary complexes | ||
| - | **[[2kkf]] – hKHMT Hrx CxxC domain + | + | **[[2kkf]] – hKHMT Hrx CxxC domain + DNA – NMR<br /> |
**[[4nw3]] – hKHMT Mll CxxC domain + DNA <br /> | **[[4nw3]] – hKHMT Mll CxxC domain + DNA <br /> | ||
**[[4pzi]] – hKHMT CxxC domain + DNA <br /> | **[[4pzi]] – hKHMT CxxC domain + DNA <br /> | ||
| - | **[[3q0b]], [[3q0c]], [[3q0d]], [[3q0f]] – hKHMT SRA domain + | + | **[[3q0b]], [[3q0c]], [[3q0d]], [[3q0f]] – hKHMT SRA domain + DNA <br /> |
**[[3qow]] – hKHMT + SAM <br /> | **[[3qow]] – hKHMT + SAM <br /> | ||
**[[4fmu]] – hKHMT SETD2 + inhibitor <br /> | **[[4fmu]] – hKHMT SETD2 + inhibitor <br /> | ||
Revision as of 09:40, 24 March 2016
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3D Structures of histone methyltransferase
Updated on 24-March-2016
References
- ↑ Trievel RC. Structure and function of histone methyltransferases. Crit Rev Eukaryot Gene Expr. 2004;14(3):147-69. PMID:15248813
- ↑ Ferguson AD, Larsen NA, Howard T, Pollard H, Green I, Grande C, Cheung T, Garcia-Arenas R, Cowen S, Wu J, Godin R, Chen H, Keen N. Structural Basis of Substrate Methylation and Inhibition of SMYD2. Structure. 2011 Jul 20. PMID:21782458 doi:10.1016/j.str.2011.06.011
- ↑ Greer EL, Shi Y. Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet. 2012 Apr 3;13(5):343-57. doi: 10.1038/nrg3173. PMID:22473383 doi:http://dx.doi.org/10.1038/nrg3173
- ↑ Xiao B, Jing C, Wilson JR, Walker PA, Vasisht N, Kelly G, Howell S, Taylor IA, Blackburn GM, Gamblin SJ. Structure and catalytic mechanism of the human histone methyltransferase SET7/9. Nature. 2003 Feb 6;421(6923):652-6. Epub 2003 Jan 22. PMID:12540855 doi:10.1038/nature01378
