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Hyaluronidase
From Proteopedia
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<StructureSection load="1c82" size="350" color="" frame="true" spin="on" Scene= caption='Hyaluronidase complex with hyaluronic acid disaccharide and dimethylarsinate, [[1c82]]' > | <StructureSection load="1c82" size="350" color="" frame="true" spin="on" Scene= caption='Hyaluronidase complex with hyaluronic acid disaccharide and dimethylarsinate, [[1c82]]' > | ||
| + | == Function == | ||
| + | '''Hyaluronidase''' (HU) hydrolyzes complex carbohydrates such as hyaluronan which is part of the extracellular matrix. The hydrolysis increases tissue permeability. | ||
| - | + | == Relevance == | |
| + | HU is used in medicine to speed drug delivery. Hyaluronic acid (HUA) is a popular dermal filler material. | ||
{| | {| | ||
|-valign="top" | |-valign="top" | ||
Revision as of 08:15, 27 March 2016
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3D structures of hyaluronidase
Updated on 27-March-2016
Reference
Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis., Chao KL, Muthukumar L, Herzberg O, Biochemistry. 2007 Jun 12;46(23):6911-20. Epub 2007 May 16. PMID:17503783
Created with the participation of Osnat Herzberg, Eran Hodis, Joel L. Sussman, Jaime Prilusky.
