This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Hydroxysteroid dehydrogenase
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
'''Hydroxysteroid dehydrogenase''' (HSD) catalyzes the dehydrogenation of hydroxysteroids. HSD is classified according to the number of the carbon it is acting on.<br /> | '''Hydroxysteroid dehydrogenase''' (HSD) catalyzes the dehydrogenation of hydroxysteroids. HSD is classified according to the number of the carbon it is acting on.<br /> | ||
* '''3-α HSD''' catalyzes the conversion of androsterone to 5α-androstane-3, 17-dione and 17-α estradiol to estrone. 3-α HSD (also named 17-α HSD) is a bile acid-metabolizing enzyme.<br /> | * '''3-α HSD''' catalyzes the conversion of androsterone to 5α-androstane-3, 17-dione and 17-α estradiol to estrone. 3-α HSD (also named 17-α HSD) is a bile acid-metabolizing enzyme.<br /> | ||
| - | * '''7-α HSD''' is involved in the dehydrogenation of cholanate compounds and is a bile acid-inducible enzyme.<br /> | + | * '''7-α HSD''' is involved in the dehydrogenation of cholanate compounds and is a bile acid-inducible enzyme<ref>PMID:786279</ref>.<br /> |
| - | * '''20-α HSD''' is involved in the control of progesterone level in pregnancy of mice.<br /> | + | * '''20-α HSD''' is involved in the control of progesterone level in pregnancy of mice<ref>PMID:17122075</ref>.<br /> |
| - | * '''11-β HSD''' converts 11-keto products like cortisone to cortisol.<br /> | + | * '''11-β HSD''' converts 11-keto products like cortisone to cortisol<ref>PMID:15466942</ref>.<br /> |
| - | * '''17-β HSD''' is involved in the conversion of androstenedione to testosterone.<br /> | + | * '''17-β HSD''' is involved in the conversion of androstenedione to testosterone<ref>PMID:9029730</ref>.<br /> |
| - | * '''3-β/17-β HSD''' catalyzes the reversible dehydrogenation of steroid compounds at position 3 and 17.<br /> | + | * '''3-β/17-β HSD''' catalyzes the reversible dehydrogenation of steroid compounds at position 3 and 17<ref>PMID:1309351</ref>.<br /> |
[[NAD]] and NADP are cofactors of HSD. | [[NAD]] and NADP are cofactors of HSD. | ||
| Line 132: | Line 132: | ||
**[[1hxh ]] - CtHSD | **[[1hxh ]] - CtHSD | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:16, 27 March 2016
Hydroxysteroid dehydrogenase (HSD) catalyzes the dehydrogenation of hydroxysteroids. HSD is classified according to the number of the carbon it is acting on.
- 3-α HSD catalyzes the conversion of androsterone to 5α-androstane-3, 17-dione and 17-α estradiol to estrone. 3-α HSD (also named 17-α HSD) is a bile acid-metabolizing enzyme.
- 7-α HSD is involved in the dehydrogenation of cholanate compounds and is a bile acid-inducible enzyme[1].
- 20-α HSD is involved in the control of progesterone level in pregnancy of mice[2].
- 11-β HSD converts 11-keto products like cortisone to cortisol[3].
- 17-β HSD is involved in the conversion of androstenedione to testosterone[4].
- 3-β/17-β HSD catalyzes the reversible dehydrogenation of steroid compounds at position 3 and 17[5].
NAD and NADP are cofactors of HSD.
3D structures of hydroxysteroid dehydrogenase
Updated on 27-March-2016
For 3-α HSD type 2 see Prostaglandin F synthase
For 17-β HSD type 5 see Prostaglandin F synthase
References
- ↑ Haslewood ES, Haslewood GA. The specificity of a 7 alpha-hydroxy steroid dehydrogenase from Escherichia coli. Biochem J. 1976 Jul 1;157(1):207-10. PMID:786279
- ↑ Hershkovitz L, Beuschlein F, Klammer S, Krup M, Weinstein Y. Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone. Endocrinology. 2007 Mar;148(3):976-88. Epub 2006 Nov 22. PMID:17122075 doi:http://dx.doi.org/10.1210/en.2006-1100
- ↑ Tomlinson JW, Walker EA, Bujalska IJ, Draper N, Lavery GG, Cooper MS, Hewison M, Stewart PM. 11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response. Endocr Rev. 2004 Oct;25(5):831-66. PMID:15466942 doi:http://dx.doi.org/10.1210/er.2003-0031
- ↑ Labrie F, Luu-The V, Lin SX, Labrie C, Simard J, Breton R, Belanger A. The key role of 17 beta-hydroxysteroid dehydrogenases in sex steroid biology. Steroids. 1997 Jan;62(1):148-58. PMID:9029730
- ↑ de Launoit Y, Simard J, Durocher F, Labrie F. Androgenic 17 beta-hydroxysteroid dehydrogenase activity of expressed rat type I 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase. Endocrinology. 1992 Jan;130(1):553-5. PMID:1309351 doi:http://dx.doi.org/10.1210/endo.130.1.1309351
